FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079427883> ?p ?o ?g. }

• W2079427883 endingPage "404" @default.
• W2079427883 startingPage "393" @default.
• W2079427883 abstract "Development of neutralizing antibodies (NAbs) to interferons (IFNs) can reduce the clinical response to IFN therapy. As current cell-based assays for quantifying NAbs have limitations, a highly sensitive and reproducible assay was developed, using division-arrested frozen human U937 cells transfected with the luciferase reportergene controlled by an IFN-responsive chimeric promoter, which allows IFN activity to be determined with precision within hours. Assay-ready PIL5 cells can be stored frozen for >3 years without loss of IFN sensitivity or the need for cell propagation. The assay is highly IFN sensitive (detecting <1.0 IU/mL), reproducible (SE +/- 15%) over concentrations from <1.0 to 100 IU/mL and able to measure different IFN subtypes and their pegylated variants. The use of this assay has shown that NAbs from patients treated with IFN-alpha2 exhibited markedly lower titers against 10 LU/mL of low specific activity IFNs, namely, IFN-alpha1, PEG-Intron(TM) (Schering-Plough, Levallois-Perret,France), or Pegasys(TM) (Hoffmann-La Roche, Neuilly-sur-Seine, France, than against 10 LU/mL IFN-alpha2. Similarly, NAbs from patients treated with IFN-beta1a exhibit lower titers against 10 LU/mL of low specific activity IFN-beta1b than against IFN-beta1a. The combination of the use of division-arrested, IFN-responsive human cells transfected with the luciferase reporter-gene makes the rapid PIL5 assay for NAbs highly advantageous." @default.
• W2079427883 created "2016-06-24" @default.
• W2079427883 creator A5005781064 @default.
• W2079427883 creator A5006415762 @default.
• W2079427883 creator A5008094918 @default.
• W2079427883 creator A5019490953 @default.
• W2079427883 creator A5077580993 @default.
• W2079427883 creator A5081955768 @default.
• W2079427883 creator A5084465694 @default.
• W2079427883 creator A5086726916 @default.
• W2079427883 date "2008-06-01" @default.
• W2079427883 modified "2023-10-04" @default.
• W2079427883 title "Quantification of Neutralizing Antibodies to Human Type I Interferons Using Division-Arrested Frozen Cells Carrying an Interferon-Regulated Reporter-Gene" @default.
• W2079427883 cites W1968010370 @default.
• W2079427883 cites W1997745815 @default.
• W2079427883 cites W2004969412 @default.
• W2079427883 cites W2017476323 @default.
• W2079427883 cites W2038229899 @default.
• W2079427883 cites W2045136965 @default.
• W2079427883 cites W2060572566 @default.
• W2079427883 cites W2073616208 @default.
• W2079427883 cites W2076684594 @default.
• W2079427883 cites W2095416682 @default.
• W2079427883 cites W2096569053 @default.
• W2079427883 cites W2099121549 @default.
• W2079427883 cites W2154978234 @default.
• W2079427883 cites W2161552221 @default.
• W2079427883 cites W2162083196 @default.
• W2079427883 cites W2166157222 @default.
• W2079427883 cites W2174908949 @default.
• W2079427883 cites W2188625919 @default.
• W2079427883 cites W68810031 @default.
• W2079427883 doi "https://doi.org/10.1089/jir.2007.0142" @default.
• W2079427883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18593334" @default.
• W2079427883 hasPublicationYear "2008" @default.
• W2079427883 type Work @default.
• W2079427883 sameAs 2079427883 @default.
• W2079427883 citedByCount "48" @default.
• W2079427883 countsByYear W20794278832012 @default.
• W2079427883 countsByYear W20794278832013 @default.
• W2079427883 countsByYear W20794278832014 @default.
• W2079427883 countsByYear W20794278832015 @default.
• W2079427883 countsByYear W20794278832016 @default.
• W2079427883 countsByYear W20794278832017 @default.
• W2079427883 countsByYear W20794278832019 @default.
• W2079427883 countsByYear W20794278832021 @default.
• W2079427883 crossrefType "journal-article" @default.
• W2079427883 hasAuthorship W2079427883A5005781064 @default.
• W2079427883 hasAuthorship W2079427883A5006415762 @default.
• W2079427883 hasAuthorship W2079427883A5008094918 @default.
• W2079427883 hasAuthorship W2079427883A5019490953 @default.
• W2079427883 hasAuthorship W2079427883A5077580993 @default.
• W2079427883 hasAuthorship W2079427883A5081955768 @default.
• W2079427883 hasAuthorship W2079427883A5084465694 @default.
• W2079427883 hasAuthorship W2079427883A5086726916 @default.
• W2079427883 hasConcept C104317684 @default.
• W2079427883 hasConcept C111335760 @default.
• W2079427883 hasConcept C150194340 @default.
• W2079427883 hasConcept C153911025 @default.
• W2079427883 hasConcept C159047783 @default.
• W2079427883 hasConcept C159654299 @default.
• W2079427883 hasConcept C161733203 @default.
• W2079427883 hasConcept C185592680 @default.
• W2079427883 hasConcept C203014093 @default.
• W2079427883 hasConcept C2776178377 @default.
• W2079427883 hasConcept C2779261636 @default.
• W2079427883 hasConcept C32611913 @default.
• W2079427883 hasConcept C54009773 @default.
• W2079427883 hasConcept C54355233 @default.
• W2079427883 hasConcept C553184892 @default.
• W2079427883 hasConcept C55493867 @default.
• W2079427883 hasConcept C81885089 @default.
• W2079427883 hasConcept C86803240 @default.
• W2079427883 hasConceptScore W2079427883C104317684 @default.
• W2079427883 hasConceptScore W2079427883C111335760 @default.
• W2079427883 hasConceptScore W2079427883C150194340 @default.
• W2079427883 hasConceptScore W2079427883C153911025 @default.
• W2079427883 hasConceptScore W2079427883C159047783 @default.
• W2079427883 hasConceptScore W2079427883C159654299 @default.
• W2079427883 hasConceptScore W2079427883C161733203 @default.
• W2079427883 hasConceptScore W2079427883C185592680 @default.
• W2079427883 hasConceptScore W2079427883C203014093 @default.
• W2079427883 hasConceptScore W2079427883C2776178377 @default.
• W2079427883 hasConceptScore W2079427883C2779261636 @default.
• W2079427883 hasConceptScore W2079427883C32611913 @default.
• W2079427883 hasConceptScore W2079427883C54009773 @default.
• W2079427883 hasConceptScore W2079427883C54355233 @default.
• W2079427883 hasConceptScore W2079427883C553184892 @default.
• W2079427883 hasConceptScore W2079427883C55493867 @default.
• W2079427883 hasConceptScore W2079427883C81885089 @default.
• W2079427883 hasConceptScore W2079427883C86803240 @default.
• W2079427883 hasIssue "6" @default.
• W2079427883 hasLocation W20794278831 @default.
• W2079427883 hasLocation W20794278832 @default.
• W2079427883 hasOpenAccess W2079427883 @default.
• W2079427883 hasPrimaryLocation W20794278831 @default.
• W2079427883 hasRelatedWork W1533033160 @default.
• W2079427883 hasRelatedWork W1972745941 @default.

• next