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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079432029> ?p ?o ?g. }

• W2079432029 endingPage "539" @default.
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• W2079432029 abstract "A novel non-pyrogenic carbocyclic muramyl dipeptide (MDP) analogue, N-¿trans-2-[[2'-(acetylamino)cyclohexyl]oxy]acetyl¿-L-alanyl-D-glutamic acid, was obtained by replacement of the N-acetylmuramic acid part and the D-isoglutamine residue of the MDP molecule by a trans-2-[[2'-(acetylamino)cyclohexyl]oxy]acetyl moiety and D-glutamic acid, respectively. The title compound was selected as a promising candidate for further evaluation among several related analogues on the basis of an immunorestoration test in mice. This novel nor-MDP analogue protects mice against the immunosuppressive effect of cyclophosphamide and increases the nonspecific resistance of mice against fungal infection. It is an immunomodulator which enhances the maturation of lymphocytes B to plasma cells and increases the activity of lymphocytes B and lymphocytes T as well as that of macrophages but does not alter the number of these cells." @default.
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• W2079432029 date "1998-01-28" @default.
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• W2079432029 title "<i>N</i>-{<i>trans</i>-2-[[2‘-(Acetylamino)cyclohexyl]oxy]acetyl}-<scp>l</scp>-alanyl-<scp>d</scp>-glutamic Acid: A Novel Immunologically Active Carbocyclic Muramyl Dipeptide Analogue" @default.
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• W2079432029 doi "https://doi.org/10.1021/jm970509d" @default.
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