FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079433650> ?p ?o ?g. }

• W2079433650 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCNasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignancy that is particularly prevalent in Asia. The main challenges in the management of NPC include late presentation and severe side effects of chemo-radiotherapies due to the close proximity of tumours to vital structures. Two bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), which signal through G protein-coupled receptors, regulate many biological processes associated with tumour development and progression. Therefore, LPA and S1P have emerged as potential targets in cancer therapies, but the roles of these lipid molecules in the pathogenesis of NPC have not been investigated. Microarray analyses revealed differential expression of several key regulators of LPA and S1P metabolism in NPC cells compared to non-malignant nasopharyngeal epithelium. Imunohistochemical studies showed that autotaxin and SPHK1, the key enzymes involved in the production of LPA and S1P, respectively, were expressed by the tumour cells in primary NPC tissues. QPCR analyses demonstrated that an EBV-positive NPC cell line, C666-1, expressed higher levels of autotaxin and SPHK1 as compared to six EBV-negative NPC cell lines, suggesting that EBV infection might contribute to the de-regulation of phospholipid signalling in NPC. The microarray data showed that LPA receptor 5 (LPA5) was significantly down-regulated in primary NPC tissues and, similarly, LPA5 protein expression in tumour cells was weak or absent in 17/22 primary NPC cases. Consistent with these findings, LPA5 mRNA levels were significantly lower in a panel of six EBV-infected cell lines than in non-infected controls. By treating NPC cell lines with exogenous LPA, we showed that LPA enhanced the migration of NPC cells in vitro. Given that NPC is characterised by prominent lymphocyte infiltration, the effect of LPA on cells within the NPC tumour microenvironment was examined by treating several clones of EBV-specific cytotoxic T lymphocytes (CTLs) in vitro. LPA inhibited the secretion of IFN-γ from peptide stimulated CTLs in a dose-dependent manner, indicating that LPA could inhibit CTL function. Collectively, our results demonstrate that LPA and S1P signalling are de-regulated in NPC. Aberrant LPA production may promote a more aggressive phenotype in NPC and EBV infection might contribute to the aberrant LPA signalling by down-regulating LPA5. Targeting LPA and/or its signalling pathways might represent a novel therapeutic strategy with which to improve the efficiency of EBV-based CTL therapy in NPC patients.Citation Format: Lee-Fah Yap, Christopher W. Dawson, Rajadurai Pathmanathan, Hui-Min Lee, Paul Lim, Tracey Haigh, John R. Arrand, Graham S. Taylor, Ian C. Paterson, Paul G. Murray. Aberrant phospholipid signalling in EBV-associated nasopharyngeal carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4263. doi:10.1158/1538-7445.AM2013-4263" @default.
• W2079433650 created "2016-06-24" @default.
• W2079433650 creator A5004694927 @default.
• W2079433650 creator A5012281019 @default.
• W2079433650 creator A5016051848 @default.
• W2079433650 creator A5017842948 @default.
• W2079433650 creator A5027733786 @default.
• W2079433650 creator A5068113070 @default.
• W2079433650 creator A5074230622 @default.
• W2079433650 creator A5084702053 @default.
• W2079433650 creator A5085912796 @default.
• W2079433650 creator A5088625486 @default.
• W2079433650 date "2013-04-15" @default.
• W2079433650 modified "2023-09-25" @default.
• W2079433650 title "Abstract 4263: Aberrant phospholipid signalling in EBV-associated nasopharyngeal carcinoma." @default.
• W2079433650 doi "https://doi.org/10.1158/1538-7445.am2013-4263" @default.
• W2079433650 hasPublicationYear "2013" @default.
• W2079433650 type Work @default.
• W2079433650 sameAs 2079433650 @default.
• W2079433650 citedByCount "0" @default.
• W2079433650 crossrefType "proceedings-article" @default.
• W2079433650 hasAuthorship W2079433650A5004694927 @default.
• W2079433650 hasAuthorship W2079433650A5012281019 @default.
• W2079433650 hasAuthorship W2079433650A5016051848 @default.
• W2079433650 hasAuthorship W2079433650A5017842948 @default.
• W2079433650 hasAuthorship W2079433650A5027733786 @default.
• W2079433650 hasAuthorship W2079433650A5068113070 @default.
• W2079433650 hasAuthorship W2079433650A5074230622 @default.
• W2079433650 hasAuthorship W2079433650A5084702053 @default.
• W2079433650 hasAuthorship W2079433650A5085912796 @default.
• W2079433650 hasAuthorship W2079433650A5088625486 @default.
• W2079433650 hasConcept C104317684 @default.
• W2079433650 hasConcept C121608353 @default.
• W2079433650 hasConcept C126322002 @default.
• W2079433650 hasConcept C150194340 @default.
• W2079433650 hasConcept C170493617 @default.
• W2079433650 hasConcept C193270364 @default.
• W2079433650 hasConcept C2776661833 @default.
• W2079433650 hasConcept C2778703144 @default.
• W2079433650 hasConcept C2778997737 @default.
• W2079433650 hasConcept C37547375 @default.
• W2079433650 hasConcept C502942594 @default.
• W2079433650 hasConcept C509974204 @default.
• W2079433650 hasConcept C54355233 @default.
• W2079433650 hasConcept C55493867 @default.
• W2079433650 hasConcept C61705674 @default.
• W2079433650 hasConcept C71924100 @default.
• W2079433650 hasConcept C8415881 @default.
• W2079433650 hasConcept C86803240 @default.
• W2079433650 hasConcept C95444343 @default.
• W2079433650 hasConceptScore W2079433650C104317684 @default.
• W2079433650 hasConceptScore W2079433650C121608353 @default.
• W2079433650 hasConceptScore W2079433650C126322002 @default.
• W2079433650 hasConceptScore W2079433650C150194340 @default.
• W2079433650 hasConceptScore W2079433650C170493617 @default.
• W2079433650 hasConceptScore W2079433650C193270364 @default.
• W2079433650 hasConceptScore W2079433650C2776661833 @default.
• W2079433650 hasConceptScore W2079433650C2778703144 @default.
• W2079433650 hasConceptScore W2079433650C2778997737 @default.
• W2079433650 hasConceptScore W2079433650C37547375 @default.
• W2079433650 hasConceptScore W2079433650C502942594 @default.
• W2079433650 hasConceptScore W2079433650C509974204 @default.
• W2079433650 hasConceptScore W2079433650C54355233 @default.
• W2079433650 hasConceptScore W2079433650C55493867 @default.
• W2079433650 hasConceptScore W2079433650C61705674 @default.
• W2079433650 hasConceptScore W2079433650C71924100 @default.
• W2079433650 hasConceptScore W2079433650C8415881 @default.
• W2079433650 hasConceptScore W2079433650C86803240 @default.
• W2079433650 hasConceptScore W2079433650C95444343 @default.
• W2079433650 hasLocation W20794336501 @default.
• W2079433650 hasOpenAccess W2079433650 @default.
• W2079433650 hasPrimaryLocation W20794336501 @default.
• W2079433650 hasRelatedWork W2003452221 @default.
• W2079433650 hasRelatedWork W2013686404 @default.
• W2079433650 hasRelatedWork W2044023110 @default.
• W2079433650 hasRelatedWork W2053121131 @default.
• W2079433650 hasRelatedWork W2084866832 @default.
• W2079433650 hasRelatedWork W2091646605 @default.
• W2079433650 hasRelatedWork W2131005225 @default.
• W2079433650 hasRelatedWork W2313027065 @default.
• W2079433650 hasRelatedWork W2322367810 @default.
• W2079433650 hasRelatedWork W2323075010 @default.
• W2079433650 hasRelatedWork W2566692123 @default.
• W2079433650 hasRelatedWork W2624651286 @default.
• W2079433650 hasRelatedWork W2887850533 @default.
• W2079433650 hasRelatedWork W2955660245 @default.
• W2079433650 hasRelatedWork W2968368385 @default.
• W2079433650 hasRelatedWork W2969088588 @default.
• W2079433650 hasRelatedWork W2985508025 @default.
• W2079433650 hasRelatedWork W2995859923 @default.
• W2079433650 hasRelatedWork W3114258431 @default.
• W2079433650 hasRelatedWork W3205322071 @default.
• W2079433650 isParatext "false" @default.
• W2079433650 isRetracted "false" @default.
• W2079433650 magId "2079433650" @default.
• W2079433650 workType "article" @default.