Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079434650> ?p ?o ?g. }
- W2079434650 endingPage "171" @default.
- W2079434650 startingPage "149" @default.
- W2079434650 abstract "NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against reactive forms of oxygen and inhibition of neoplasia. Under conditions of oxidative stress, expression of NQO1 is induced, and the resulting increase in oxidoreductase protein provides the cell with multiple layers of protection against environmental insults. Firstly, the catalytic activity of NQO1 is directed towards the complete reduction and detoxication of highly reactive quinones. Secondly, the oxidoreductase maintains the endogenous lipid-soluble antioxidants, α-tocopherol-hydroquinone and ubiquinol in their reduced and active forms. Thirdly, NQO1 is required for the stabilisation of p53 protein in response to DNA-damaging stimuli, and it thereby influences cell fate decisions. In view of the anticarcinogenic actions of NQO1, an understanding of the mechanisms that govern its expression is desirable. The redox sensitivity of NQO1 transcription occurs through a cis-acting antioxidant response element (ARE) located within the regulatory region of the mouse, rat and human genes. This element recruits the positively acting basic leucine zipper (bZip) transcription factor NF-E2 p45-related factor 2 (Nrf2). Under normal constitutive conditions, Nrf2 associates with the cytoskeletal-binding protein Keap1, which regulates the subcellular distribution of the bZip factor and also targets it for proteasome-dependent degradation. Oxidative stress inhibits the Nrf2–Keap1 interaction, thus promoting nuclear accumulation of the transcription factor and transactivation of NQO1 and other ARE-driven genes. Mouse, rat and human NQO1 can also be induced by planar aromatic hydrocarbons through a cis-acting xenobiotic response element (XRE) located in their gene promoters. The XRE recruits the arylhydrocarbon receptor (AhR) and AhR nuclear translocator. Cross-talk may occur between Nrf2 and AhR, but the details of this process remain to be elucidated." @default.
- W2079434650 created "2016-06-24" @default.
- W2079434650 creator A5004125788 @default.
- W2079434650 creator A5046024649 @default.
- W2079434650 date "2004-11-01" @default.
- W2079434650 modified "2023-10-02" @default.
- W2079434650 title "Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors" @default.
- W2079434650 cites W1481950549 @default.
- W2079434650 cites W1486489467 @default.
- W2079434650 cites W1492029572 @default.
- W2079434650 cites W1493240590 @default.
- W2079434650 cites W1499795865 @default.
- W2079434650 cites W1503877859 @default.
- W2079434650 cites W1505849639 @default.
- W2079434650 cites W1508395055 @default.
- W2079434650 cites W1508847987 @default.
- W2079434650 cites W1528115421 @default.
- W2079434650 cites W1533811499 @default.
- W2079434650 cites W1544674423 @default.
- W2079434650 cites W1545314652 @default.
- W2079434650 cites W1546537221 @default.
- W2079434650 cites W1561096292 @default.
- W2079434650 cites W1561656160 @default.
- W2079434650 cites W1577468157 @default.
- W2079434650 cites W1581676497 @default.
- W2079434650 cites W1598160264 @default.
- W2079434650 cites W1603979475 @default.
- W2079434650 cites W1604748982 @default.
- W2079434650 cites W1650797637 @default.
- W2079434650 cites W1816432249 @default.
- W2079434650 cites W1822743979 @default.
- W2079434650 cites W1858268805 @default.
- W2079434650 cites W1900938706 @default.
- W2079434650 cites W1917529770 @default.
- W2079434650 cites W1925723678 @default.
- W2079434650 cites W1967692811 @default.
- W2079434650 cites W1972626671 @default.
- W2079434650 cites W1973141016 @default.
- W2079434650 cites W1974437991 @default.
- W2079434650 cites W1974684319 @default.
- W2079434650 cites W1976257479 @default.
- W2079434650 cites W1977229794 @default.
- W2079434650 cites W1978018487 @default.
- W2079434650 cites W1982805396 @default.
- W2079434650 cites W1989541636 @default.
- W2079434650 cites W1990598806 @default.
- W2079434650 cites W1990780198 @default.
- W2079434650 cites W1990927292 @default.
- W2079434650 cites W1991494214 @default.
- W2079434650 cites W1991530716 @default.
- W2079434650 cites W1991631628 @default.
- W2079434650 cites W1995445783 @default.
- W2079434650 cites W1995633773 @default.
- W2079434650 cites W1997506075 @default.
- W2079434650 cites W2001051081 @default.
- W2079434650 cites W2002801265 @default.
- W2079434650 cites W2010234159 @default.
- W2079434650 cites W2015243552 @default.
- W2079434650 cites W2017319763 @default.
- W2079434650 cites W2018693799 @default.
- W2079434650 cites W2024568523 @default.
- W2079434650 cites W2025039508 @default.
- W2079434650 cites W2028323326 @default.
- W2079434650 cites W2030867249 @default.
- W2079434650 cites W2033802853 @default.
- W2079434650 cites W2038376109 @default.
- W2079434650 cites W2040114786 @default.
- W2079434650 cites W2041937485 @default.
- W2079434650 cites W2045965817 @default.
- W2079434650 cites W2046567614 @default.
- W2079434650 cites W2046750894 @default.
- W2079434650 cites W2047344689 @default.
- W2079434650 cites W2047702806 @default.
- W2079434650 cites W2048700223 @default.
- W2079434650 cites W2051690606 @default.
- W2079434650 cites W2052243794 @default.
- W2079434650 cites W2052548231 @default.
- W2079434650 cites W2053063855 @default.
- W2079434650 cites W2053671318 @default.
- W2079434650 cites W2053919910 @default.
- W2079434650 cites W2055110079 @default.
- W2079434650 cites W2056650214 @default.
- W2079434650 cites W2059240823 @default.
- W2079434650 cites W2060145043 @default.
- W2079434650 cites W2062371429 @default.
- W2079434650 cites W2063179005 @default.
- W2079434650 cites W2066067744 @default.
- W2079434650 cites W2068642882 @default.
- W2079434650 cites W2072368664 @default.
- W2079434650 cites W2075266560 @default.
- W2079434650 cites W2076405456 @default.
- W2079434650 cites W2076569763 @default.
- W2079434650 cites W2079596789 @default.
- W2079434650 cites W2079892215 @default.
- W2079434650 cites W2080435498 @default.
- W2079434650 cites W2081737819 @default.
- W2079434650 cites W2083287953 @default.
- W2079434650 cites W2083848894 @default.