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• W2079436029 abstract "In an attempt to stimulate granulopoiesis, we administered recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) to 11 patients with lymphoprolif-erative disorders. Ten patients had neutropenia, six of whom had severe neutropenia (<500 neutrophils), including two with agranulocytosis. GM-CSF (60-250 μg/m2/day) was administered by continuous intravenous infusion daily for 14 days at 2-week intervals. Significant increases in white blood cell counts (1.3- to 11.7-fold) and neutrophils (1.7- to more than 29-fold) were seen in 10 of 11 patients, including one patient with agranulocytosis. Eosinophils (3.9- to > 65-fold) and monocytes (1.3- to >5-fold) increased as well. In contrast, no significant increases were seen in total lymphocytes or in different phenotypic subsets of lymphocytes during treatment. The overall proportion of myeloid and lymphoid elements in bone marrow remained stable. These results indicate that GM-CSF is effective in stimulating myelopoiesis in neutropenic states associated with lymphopro-liferative disorders. Further studies will be necessary to determine whether the correction of neutropenia ultimately translates into clinical benefit." @default.
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• W2079436029 date "1990-03-01" @default.
• W2079436029 modified "2023-10-17" @default.
• W2079436029 title "Stimulation of myelopoiesis in chronic lymphocytic leukemia and in other lymphoproliferative disorders by recombinant human granulocyte-macrophage colony-stimulating factor" @default.
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• W2079436029 doi "https://doi.org/10.1002/ajh.2830330307" @default.
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