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- W2079436045 abstract "1 The effects of the putative α1B-adrenoceptor antagonist, chloroethylclonidine (CEC), on tension responses of the rat isolated whole vas deferens to single and multiple pulses of electrical field stimulation have been evaluated by use of a microcomputer system which enables the averaging of like-responses throughout their time course. 2 CEC (10−7 to 3 × 10−6 m) selectively and in a concentration-dependent manner blocked the noradrenergic component of the response to a single field stimulus in the absence or presence of nifedipine (10−5 m, which blocked the purinergic but not the noradrenergic component of the response). The concentration-response curve of the vas to exogenously-applied noradrenaline (NA) was unaffected by CEC (10−6 m) but was flattened by nifedipine (10−5 m). 3 The tension response to 10 Hz trains of pulses was biphasic, with an early (< 2 s) and a plateau (> 4 s) phase. We deduce from our pharmacological analysis that the early phase contains a putative α1B-adrenoceptor component (susceptible to CEC or prazosin but not to nifedipine) and a P2-purinoceptor component (susceptible to suramin or nifedipine) whereas the plateau phase contains an α1A-adrenoceptor component (susceptible to prazosin or nifedipine but not to CEC) and a P2-purinoceptor component (susceptible to suramin or nifedipine). 4 We suggest that the putative α1B-adrenoceptors may be functionally confined to the synaptic region whereas the putative α1A-adrenoceptors are excluded from this region. Trains of pulses would allow NA to accumulate and spill out beyond the synaptic region to reach and activate the putative α1A-adrenoceptors." @default.
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- W2079436045 date "1992-03-01" @default.
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- W2079436045 title "Separation of putative α1A- and α1B- adrenoceptor mediated components in the tension response of the rat vas deferens to electrical field stimulation" @default.
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- W2079436045 doi "https://doi.org/10.1111/j.1476-5381.1992.tb09046.x" @default.
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