Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079436242> ?p ?o ?g. }
- W2079436242 endingPage "60" @default.
- W2079436242 startingPage "52" @default.
- W2079436242 abstract "The development of the bystander effect induced by low doses of irradiation in human umbilical vein endothelial cells (HUVECs) depends on extracellular DNA (ecDNA) signaling pathway. We found that the changes in the levels of ROS and NO production by human endothelial cells are components of the radiation induced bystander effect that can be registered at a low dose. We exposed HUVECs to X-ray radiation and studied effects of ecDNAR isolated from the culture media conditioned by the short-term incubation of irradiated cells on intact HUVECs. Effects of ecDNAR produced by irradiated cells on ROS and NO production in non-irradiated HUVECs are similar to bystander effect. These effects at least partially depend on TLR9 signaling. We compared the production of the nitric oxide and the ROS in human endothelial cells that were (1) irradiated at a low dose; (2) exposed to the ecDNAR extracted from the media conditioned by irradiated cells; and (3) exposed to human DNA oxidized in vitro. We found that the cellular responses to all three stimuli described above are essentially similar. We conclude that irradiation-related oxidation of the ecDNA is an important component of the ecDNA-mediated bystander effect." @default.
- W2079436242 created "2016-06-24" @default.
- W2079436242 creator A5013782053 @default.
- W2079436242 creator A5014201510 @default.
- W2079436242 creator A5031560265 @default.
- W2079436242 creator A5047467632 @default.
- W2079436242 creator A5063168552 @default.
- W2079436242 creator A5065986636 @default.
- W2079436242 creator A5067141644 @default.
- W2079436242 creator A5079881874 @default.
- W2079436242 date "2012-01-01" @default.
- W2079436242 modified "2023-09-30" @default.
- W2079436242 title "Role of extracellular DNA oxidative modification in radiation induced bystander effects in human endotheliocytes" @default.
- W2079436242 cites W1976821923 @default.
- W2079436242 cites W1979676330 @default.
- W2079436242 cites W1980431577 @default.
- W2079436242 cites W1985234565 @default.
- W2079436242 cites W1992725371 @default.
- W2079436242 cites W1993781414 @default.
- W2079436242 cites W1996258759 @default.
- W2079436242 cites W1997265694 @default.
- W2079436242 cites W1998428497 @default.
- W2079436242 cites W1999087883 @default.
- W2079436242 cites W1999951567 @default.
- W2079436242 cites W2004691367 @default.
- W2079436242 cites W2017626786 @default.
- W2079436242 cites W2020080089 @default.
- W2079436242 cites W2020138346 @default.
- W2079436242 cites W2021959636 @default.
- W2079436242 cites W2022568707 @default.
- W2079436242 cites W2024755124 @default.
- W2079436242 cites W2037426867 @default.
- W2079436242 cites W2038307719 @default.
- W2079436242 cites W2038326509 @default.
- W2079436242 cites W2042006175 @default.
- W2079436242 cites W2042703282 @default.
- W2079436242 cites W2052224009 @default.
- W2079436242 cites W2052350481 @default.
- W2079436242 cites W2055755227 @default.
- W2079436242 cites W2057810394 @default.
- W2079436242 cites W205975924 @default.
- W2079436242 cites W2061508611 @default.
- W2079436242 cites W2064258193 @default.
- W2079436242 cites W2071919212 @default.
- W2079436242 cites W2075479208 @default.
- W2079436242 cites W2077916251 @default.
- W2079436242 cites W2078370178 @default.
- W2079436242 cites W2081401746 @default.
- W2079436242 cites W2085640353 @default.
- W2079436242 cites W2089959863 @default.
- W2079436242 cites W2090762954 @default.
- W2079436242 cites W2101331356 @default.
- W2079436242 cites W2110106971 @default.
- W2079436242 cites W2117352925 @default.
- W2079436242 cites W2119712647 @default.
- W2079436242 cites W2128444145 @default.
- W2079436242 cites W2146451177 @default.
- W2079436242 cites W2153853960 @default.
- W2079436242 cites W2157603347 @default.
- W2079436242 cites W2163792427 @default.
- W2079436242 cites W2166522896 @default.
- W2079436242 cites W2170658762 @default.
- W2079436242 cites W2401076721 @default.
- W2079436242 cites W656188273 @default.
- W2079436242 doi "https://doi.org/10.1016/j.mrfmmm.2011.09.005" @default.
- W2079436242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22001237" @default.
- W2079436242 hasPublicationYear "2012" @default.
- W2079436242 type Work @default.
- W2079436242 sameAs 2079436242 @default.
- W2079436242 citedByCount "52" @default.
- W2079436242 countsByYear W20794362422012 @default.
- W2079436242 countsByYear W20794362422013 @default.
- W2079436242 countsByYear W20794362422014 @default.
- W2079436242 countsByYear W20794362422015 @default.
- W2079436242 countsByYear W20794362422016 @default.
- W2079436242 countsByYear W20794362422017 @default.
- W2079436242 countsByYear W20794362422018 @default.
- W2079436242 countsByYear W20794362422019 @default.
- W2079436242 countsByYear W20794362422020 @default.
- W2079436242 countsByYear W20794362422021 @default.
- W2079436242 countsByYear W20794362422022 @default.
- W2079436242 crossrefType "journal-article" @default.
- W2079436242 hasAuthorship W2079436242A5013782053 @default.
- W2079436242 hasAuthorship W2079436242A5014201510 @default.
- W2079436242 hasAuthorship W2079436242A5031560265 @default.
- W2079436242 hasAuthorship W2079436242A5047467632 @default.
- W2079436242 hasAuthorship W2079436242A5063168552 @default.
- W2079436242 hasAuthorship W2079436242A5065986636 @default.
- W2079436242 hasAuthorship W2079436242A5067141644 @default.
- W2079436242 hasAuthorship W2079436242A5079881874 @default.
- W2079436242 hasConcept C111337013 @default.
- W2079436242 hasConcept C121332964 @default.
- W2079436242 hasConcept C143425029 @default.
- W2079436242 hasConcept C153911025 @default.
- W2079436242 hasConcept C178790620 @default.
- W2079436242 hasConcept C185544564 @default.
- W2079436242 hasConcept C185592680 @default.
- W2079436242 hasConcept C19106626 @default.