FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079439158> ?p ?o ?g. }

• W2079439158 endingPage "161" @default.
• W2079439158 startingPage "155" @default.
• W2079439158 abstract "Abstract: Patients with chronic liver impairment often display symptoms of affective psychiatric nature where the choice for antidepressant treatment is rational. Since caution is recommended when these drugs are used in such patients, a dose reduction is usually performed. We have previously reported that a dose reduction to liver‐impaired portacaval shunted rats has resulted in similar brain concentrations of venlafaxine as compared to sham‐operated control rats that received a two times higher dose. The main aim of the present study was therefore to investigate if this “normalisation” in pharmacokinetics of the portacaval‐shunted rats also was true for the pharmacodynamic response in terms of drug effect on spontaneous open‐field behaviour. Thus, portacaval‐shunted rats received a single reduced dose (5 mg/kg) of venlafaxine or saline, whereas sham‐operated rats received either 10 mg/kg or saline. Thereafter, central and peripheral arena locomotor and rearing activities were recorded during 60 min. The venlafaxine‐treated portacaval‐shunted and sham rats displayed reduced and unchanged overall behavioural activities compared with corresponding controls, respectively. However, the ratios between centrally and peripherally performed behavioural activities were higher in the venlafaxine‐treated sham rats, indicating an increase in central arena activity as compared to the sham‐saline and portacaval‐shunted rats. The present study indicates that, despite a 50% dose reduction, caution still is necessary when antidepressants are used in liver insufficient subjects. This study also shows the importance of detailed open‐field behavioural studies in which both central and peripheral activities are recorded for measurement of open‐field behavioural drug effects." @default.
• W2079439158 created "2016-06-24" @default.
• W2079439158 creator A5008504020 @default.
• W2079439158 creator A5071729783 @default.
• W2079439158 creator A5077105425 @default.
• W2079439158 creator A5090493058 @default.
• W2079439158 date "2005-08-26" @default.
• W2079439158 modified "2023-10-15" @default.
• W2079439158 title "Open-Field Behavioural Alterations in Liver-Impaired and Sham-Operated Rats after Acute Exposure to the Antidepressant Venlafaxine" @default.
• W2079439158 cites W113506008 @default.
• W2079439158 cites W1588152822 @default.
• W2079439158 cites W1966497539 @default.
• W2079439158 cites W1967233463 @default.
• W2079439158 cites W1968019072 @default.
• W2079439158 cites W1975800068 @default.
• W2079439158 cites W1979540937 @default.
• W2079439158 cites W1982049192 @default.
• W2079439158 cites W1982498161 @default.
• W2079439158 cites W1984559062 @default.
• W2079439158 cites W1994911448 @default.
• W2079439158 cites W2002537665 @default.
• W2079439158 cites W2004396081 @default.
• W2079439158 cites W2008291494 @default.
• W2079439158 cites W2013052579 @default.
• W2079439158 cites W2019665762 @default.
• W2079439158 cites W2053832017 @default.
• W2079439158 cites W2055086154 @default.
• W2079439158 cites W2071765053 @default.
• W2079439158 cites W2072078906 @default.
• W2079439158 cites W2072219714 @default.
• W2079439158 cites W2072864458 @default.
• W2079439158 cites W2090692953 @default.
• W2079439158 cites W2095356032 @default.
• W2079439158 cites W277118011 @default.
• W2079439158 cites W4300096544 @default.
• W2079439158 doi "https://doi.org/10.1111/j.1742-7843.2005.pto_97385.x" @default.
• W2079439158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16128909" @default.
• W2079439158 hasPublicationYear "2005" @default.
• W2079439158 type Work @default.
• W2079439158 sameAs 2079439158 @default.
• W2079439158 citedByCount "9" @default.
• W2079439158 countsByYear W20794391582016 @default.
• W2079439158 countsByYear W20794391582017 @default.
• W2079439158 countsByYear W20794391582018 @default.
• W2079439158 countsByYear W20794391582019 @default.
• W2079439158 countsByYear W20794391582021 @default.
• W2079439158 crossrefType "journal-article" @default.
• W2079439158 hasAuthorship W2079439158A5008504020 @default.
• W2079439158 hasAuthorship W2079439158A5071729783 @default.
• W2079439158 hasAuthorship W2079439158A5077105425 @default.
• W2079439158 hasAuthorship W2079439158A5090493058 @default.
• W2079439158 hasBestOaLocation W20794391581 @default.
• W2079439158 hasConcept C111113717 @default.
• W2079439158 hasConcept C112705442 @default.
• W2079439158 hasConcept C126322002 @default.
• W2079439158 hasConcept C134018914 @default.
• W2079439158 hasConcept C2776466888 @default.
• W2079439158 hasConcept C2777214474 @default.
• W2079439158 hasConcept C2777397205 @default.
• W2079439158 hasConcept C2778808290 @default.
• W2079439158 hasConcept C2779085643 @default.
• W2079439158 hasConcept C2779177272 @default.
• W2079439158 hasConcept C2779342495 @default.
• W2079439158 hasConcept C2781161787 @default.
• W2079439158 hasConcept C2909532165 @default.
• W2079439158 hasConcept C42219234 @default.
• W2079439158 hasConcept C46762472 @default.
• W2079439158 hasConcept C71924100 @default.
• W2079439158 hasConcept C98274493 @default.
• W2079439158 hasConceptScore W2079439158C111113717 @default.
• W2079439158 hasConceptScore W2079439158C112705442 @default.
• W2079439158 hasConceptScore W2079439158C126322002 @default.
• W2079439158 hasConceptScore W2079439158C134018914 @default.
• W2079439158 hasConceptScore W2079439158C2776466888 @default.
• W2079439158 hasConceptScore W2079439158C2777214474 @default.
• W2079439158 hasConceptScore W2079439158C2777397205 @default.
• W2079439158 hasConceptScore W2079439158C2778808290 @default.
• W2079439158 hasConceptScore W2079439158C2779085643 @default.
• W2079439158 hasConceptScore W2079439158C2779177272 @default.
• W2079439158 hasConceptScore W2079439158C2779342495 @default.
• W2079439158 hasConceptScore W2079439158C2781161787 @default.
• W2079439158 hasConceptScore W2079439158C2909532165 @default.
• W2079439158 hasConceptScore W2079439158C42219234 @default.
• W2079439158 hasConceptScore W2079439158C46762472 @default.
• W2079439158 hasConceptScore W2079439158C71924100 @default.
• W2079439158 hasConceptScore W2079439158C98274493 @default.
• W2079439158 hasIssue "3" @default.
• W2079439158 hasLocation W20794391581 @default.
• W2079439158 hasLocation W20794391582 @default.
• W2079439158 hasOpenAccess W2079439158 @default.
• W2079439158 hasPrimaryLocation W20794391581 @default.
• W2079439158 hasRelatedWork W1840693314 @default.
• W2079439158 hasRelatedWork W1966637038 @default.
• W2079439158 hasRelatedWork W1979379841 @default.
• W2079439158 hasRelatedWork W1981792453 @default.
• W2079439158 hasRelatedWork W1986160850 @default.
• W2079439158 hasRelatedWork W2007043965 @default.
• W2079439158 hasRelatedWork W2062935033 @default.

• next