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• W2079439306 startingPage "243" @default.
• W2079439306 abstract "Peptides from endogenous proteins are presented by major histocompatibility complex class I molecules, but antigens (Ags) in the extracellular fluids are generally not. However, pathogens or particulate Ags that are internalized into phagosomes of macrophages (M phi s) stimulate CD8 T cells. The presentation of these Ags is resistant to chloroquine but is blocked by inhibitors of the proteasome, a mutation in the TAP1-TAP2 transporter, and brefeldin A. Moreover, phagocytosis of a ribosomal-inactivating protein inhibited M phi protein synthesis. These results demonstrate that M phi s transfer Ags from phagosomes into the cytosol and that endogenous and exogenous Ags use a final common pathway for class I presentation." @default.
• W2079439306 created "2016-06-24" @default.
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• W2079439306 creator A5082096834 @default.
• W2079439306 date "1995-01-13" @default.
• W2079439306 modified "2023-10-14" @default.
• W2079439306 title "A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules" @default.
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• W2079439306 doi "https://doi.org/10.1126/science.7809629" @default.
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