FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079445982> ?p ?o ?g. }

• W2079445982 endingPage "79" @default.
• W2079445982 startingPage "79" @default.
• W2079445982 abstract "The evidence for the integration of the submandibular gland (SMG) into the neuroimmunoregulatory network is reviewed. In laboratory rodents, factors extracted from the SMG were shown to stimulate lymphocyte proliferation, to affect the weight of the thymus, spleen and lymph nodes and to induce immunosuppression in several in vivo and in vitro models. The SMG produces significant amount of nerve growth factor (NGF), epidermal growth factor (EGF), transforming growth factor-β, and kallikreins. These factors are secreted into the saliva and affect immune and mucosal tissues and nerve endings in the gastrointestinal tract. They may thus play a role in the regulation of mucosal immune/inflammatory responses. The major salivary glands also produce antimicrobial proteins and secretory IgA antibodies which are essential factors in mucosal host defense. SMG-derived NGF, EGF and glandular kallikrein are delivered into the bloodstream where they may act as important systemic immunoregulators and exert regulatory influences on the neuroendocrine system. Growth hormone, prolactin, androgens, thyroid hormone and corticosteroids regulate protein synthesis in the SMG, where as secretory activity is regulated by sympathetic, parasympathetic and peptidergic nerve fibers. Steroid hormones and cytokines as interleukin-1α, -1β, tumor necrosis factor-α, interferon-γ have major regulatory influence on protein secretion, including the secretion of immunoglobulin into the saliva. The SMG interacts with the mucosal and systemic compartments of the immune system, with the central and peripheral nervous systems, with the pituitary gland, and with peripheral endocrine organs. These interactions enable the SMG to exert regulatory influences on immune/inflammatory reactions in the gastrointestinal tract, in the lungs, and possibly elsewhere. It is suggested that these functions make this gland a key regulatory organ in the neuroimmunoregulatory network. Biomedical Reviews 1998; 9: 79-91." @default.
• W2079445982 created "2016-06-24" @default.
• W2079445982 creator A5067544780 @default.
• W2079445982 creator A5083614033 @default.
• W2079445982 date "1998-12-31" @default.
• W2079445982 modified "2023-09-25" @default.
• W2079445982 title "Immunoregulation by the salivary glands" @default.
• W2079445982 cites W113191862 @default.
• W2079445982 cites W120212396 @default.
• W2079445982 cites W126687896 @default.
• W2079445982 cites W130559599 @default.
• W2079445982 cites W1493922302 @default.
• W2079445982 cites W1501383613 @default.
• W2079445982 cites W1506985884 @default.
• W2079445982 cites W1510532946 @default.
• W2079445982 cites W1512393880 @default.
• W2079445982 cites W1514743689 @default.
• W2079445982 cites W1522089949 @default.
• W2079445982 cites W1526390144 @default.
• W2079445982 cites W1538987641 @default.
• W2079445982 cites W1543765580 @default.
• W2079445982 cites W1575139675 @default.
• W2079445982 cites W1577472511 @default.
• W2079445982 cites W1583836391 @default.
• W2079445982 cites W1590141303 @default.
• W2079445982 cites W1596261235 @default.
• W2079445982 cites W1605241473 @default.
• W2079445982 cites W1677544667 @default.
• W2079445982 cites W1684964993 @default.
• W2079445982 cites W173357120 @default.
• W2079445982 cites W1739697637 @default.
• W2079445982 cites W1764686129 @default.
• W2079445982 cites W1766883708 @default.
• W2079445982 cites W1886267442 @default.
• W2079445982 cites W1894641937 @default.
• W2079445982 cites W1901729737 @default.
• W2079445982 cites W1909660965 @default.
• W2079445982 cites W1965188809 @default.
• W2079445982 cites W1965357068 @default.
• W2079445982 cites W1966938415 @default.
• W2079445982 cites W1967184177 @default.
• W2079445982 cites W1967561415 @default.
• W2079445982 cites W1967644583 @default.
• W2079445982 cites W1968274103 @default.
• W2079445982 cites W1970380507 @default.
• W2079445982 cites W1970446226 @default.
• W2079445982 cites W1973503426 @default.
• W2079445982 cites W1974590143 @default.
• W2079445982 cites W1976213001 @default.
• W2079445982 cites W1978910862 @default.
• W2079445982 cites W1979217973 @default.
• W2079445982 cites W1980031805 @default.
• W2079445982 cites W1985788564 @default.
• W2079445982 cites W1986018115 @default.
• W2079445982 cites W1993565704 @default.
• W2079445982 cites W2000711708 @default.
• W2079445982 cites W2002820253 @default.
• W2079445982 cites W2004662913 @default.
• W2079445982 cites W2008157672 @default.
• W2079445982 cites W2011936466 @default.
• W2079445982 cites W2016511518 @default.
• W2079445982 cites W2018572253 @default.
• W2079445982 cites W2019556941 @default.
• W2079445982 cites W2020270204 @default.
• W2079445982 cites W2020691280 @default.
• W2079445982 cites W2021655615 @default.
• W2079445982 cites W2024711621 @default.
• W2079445982 cites W2024721720 @default.
• W2079445982 cites W2030186121 @default.
• W2079445982 cites W2030923387 @default.
• W2079445982 cites W2031647876 @default.
• W2079445982 cites W2032444384 @default.
• W2079445982 cites W2034841844 @default.
• W2079445982 cites W2035715103 @default.
• W2079445982 cites W2035998803 @default.
• W2079445982 cites W2037953951 @default.
• W2079445982 cites W2038514890 @default.
• W2079445982 cites W2038680180 @default.
• W2079445982 cites W2040170605 @default.
• W2079445982 cites W2040326260 @default.
• W2079445982 cites W2047266757 @default.
• W2079445982 cites W2050674916 @default.
• W2079445982 cites W2051140711 @default.
• W2079445982 cites W2052566123 @default.
• W2079445982 cites W2054225350 @default.
• W2079445982 cites W2065109206 @default.
• W2079445982 cites W2065615069 @default.
• W2079445982 cites W2065690369 @default.
• W2079445982 cites W2069788284 @default.
• W2079445982 cites W2070841609 @default.
• W2079445982 cites W2073473087 @default.
• W2079445982 cites W2077281060 @default.
• W2079445982 cites W2080870275 @default.
• W2079445982 cites W2082317371 @default.
• W2079445982 cites W2083095729 @default.
• W2079445982 cites W2089504504 @default.
• W2079445982 cites W2090209985 @default.
• W2079445982 cites W2096271678 @default.

• next