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• W2079447458 abstract "Summary. Instigated by an increase in serious human Candida infections and aided by advances in technology, there has been renewed interest in the study of the epidemiology of fungal infections. Among the newer techniques available, contourclamped homogeneous electric field (CHEF) electrophoresis has shown great promise as a tool for typing strains of Candida albicans . However, few studies have addressed the reproducibility of the preparatory and electrophoretic methods. Through a series of analyses on clinical isolates of C. albicans , we were able to demonstrate that (a) sample preparation induced no appreciable artifacts in CHEF banding patterns; (b) the electrophoretic patterns were reproducible over time; (c) changes in colony morphology were not associated with changes in the electrophoretic pattern, and (d) the method was more sensitive than restriction enzyme analysis (REA) for demonstrating strain differences. CHEF electrophoresis is a sensitive and reproducible tool for the study of Candida epidemiology. Further use and study of this methodology is warranted. Zusammenfassung. Die Zunahme schwerer Candida ‐Infektionen sowie technologische Fortschritte haben das Interesse an der Epidemiologie von Pilzinfektionen neu belebt. Unter den neueren Techniken hat sich die CHEF‐Pulsfeldelektrophorese als vielversprechendes Werkzeug zur Stammtypisierung von Candida albicans herausgestellt. Bisher sind jedoch nur wenige Studien zur Reproduzierbarkeit der präparativen und elektrophoretischen Methoden gemacht worden. Mittels einer Serie von Analysen klinischer C. albicans ‐Isolate waren wir in der Lage zu zeigen, daß (a) die Probenpräparation keine wesentlichen Artefakte im CHEF‐Bandenmuster hervorruft, daß (b) die elektrophoretischen Muster wiederholt reproduzierbar waren, daß (c) Veränderungen in der Koloniemorphologie nicht mit Veränderungen in den elektrophoretischen Mustern verbunden waren und daß (d) die Methode empfindlicher war als die Restriktionsenzym‐Analyse (REA) für das Aufdecken von Stammunterschieden. Die CHEF‐Pulsfeldelektrophorese ist ein empfindliches und reproduzierbares Verfahren für Studien zur Candida ‐Epidemiologie. Der weitere Einsatz und weitere Untersuchungen mit dieser Methode bieten sich an." @default.
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• W2079447458 date "1995-01-01" @default.
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• W2079447458 title "Validity of contour‐clamped homogeneous electric field electrophoresis as a typing system for <i>Candida albicans</i>" @default.
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• W2079447458 doi "https://doi.org/10.1111/j.1439-0507.1995.tb00005.x" @default.
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