Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079450072> ?p ?o ?g. }
- W2079450072 endingPage "2343" @default.
- W2079450072 startingPage "2331" @default.
- W2079450072 abstract "Cell migration may depend on integrin-mediated adhesion to and deadhesion from extracellular matrix ligands. This concept, however, has not yet been confirmed for T lymphocytes migrating in three-dimensional extracellular matrices. We investigated receptor involvement in T cell migration combining a three-dimensional collagen matrix model with time-lapse videomicroscopy, computer-assisted cell tracking and confocal microscopy. In collagen lattices, the migration of CD4+ T cells (1) involved interactions with collagen fibers at the leading edge and uropod likewise, (2) occurred independently of the co-clustering of beta1, beta2, or beta3 integrins with F-actin, focal adhesion kinase, and phosphotyrosine at interactions with collagen fibers, (3) was counteracted by high-affinity beta1 integrin binding induced by antibody TS2/16; however, (4) the migration could not be blocked by a combination of adhesion-perturbing anti-beta1, -beta2, -beta3, and alpha v integrin antibodies. Integrin blocking neither affected cell polarization, interaction with fibers, beta1 integrin distribution, migration velocity, path structure, nor the number of locomoting cells in spontaneously migrating or concanavalin A-activated cells. Hence, T lymphocytes migrating in three-dimensional collagen matrices may utilize highly transient interactions with collagen fibers of low adhesivity, thereby differing from focal adhesion-dependent migration strategies employed by other cells." @default.
- W2079450072 created "2016-06-24" @default.
- W2079450072 creator A5016640976 @default.
- W2079450072 creator A5026527299 @default.
- W2079450072 creator A5063571876 @default.
- W2079450072 creator A5063904227 @default.
- W2079450072 creator A5065021872 @default.
- W2079450072 date "1998-08-01" @default.
- W2079450072 modified "2023-10-02" @default.
- W2079450072 title "CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize β1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion" @default.
- W2079450072 cites W1229524518 @default.
- W2079450072 cites W1552764442 @default.
- W2079450072 cites W1553036924 @default.
- W2079450072 cites W1559994288 @default.
- W2079450072 cites W1560549449 @default.
- W2079450072 cites W1594207045 @default.
- W2079450072 cites W1595769506 @default.
- W2079450072 cites W169876379 @default.
- W2079450072 cites W1794444991 @default.
- W2079450072 cites W1877478601 @default.
- W2079450072 cites W1898686169 @default.
- W2079450072 cites W1906447044 @default.
- W2079450072 cites W1936094671 @default.
- W2079450072 cites W1969260749 @default.
- W2079450072 cites W1976830855 @default.
- W2079450072 cites W1983212899 @default.
- W2079450072 cites W1987817886 @default.
- W2079450072 cites W1993312924 @default.
- W2079450072 cites W1994612965 @default.
- W2079450072 cites W2002499520 @default.
- W2079450072 cites W2008791808 @default.
- W2079450072 cites W2009611610 @default.
- W2079450072 cites W2040948261 @default.
- W2079450072 cites W2047204461 @default.
- W2079450072 cites W2049852173 @default.
- W2079450072 cites W2054202460 @default.
- W2079450072 cites W2060918528 @default.
- W2079450072 cites W2066367871 @default.
- W2079450072 cites W2066667739 @default.
- W2079450072 cites W2070564979 @default.
- W2079450072 cites W2092868899 @default.
- W2079450072 cites W2094280450 @default.
- W2079450072 cites W2095773895 @default.
- W2079450072 cites W2098309843 @default.
- W2079450072 cites W2102193002 @default.
- W2079450072 cites W2106532239 @default.
- W2079450072 cites W2112093320 @default.
- W2079450072 cites W2113049699 @default.
- W2079450072 cites W2114953658 @default.
- W2079450072 cites W2135096442 @default.
- W2079450072 cites W2135121318 @default.
- W2079450072 cites W2148338297 @default.
- W2079450072 cites W2172144171 @default.
- W2079450072 cites W2220655641 @default.
- W2079450072 cites W2342373848 @default.
- W2079450072 cites W2402519077 @default.
- W2079450072 cites W4376849323 @default.
- W2079450072 doi "https://doi.org/10.1002/(sici)1521-4141(199808)28:08<2331::aid-immu2331>3.0.co;2-c" @default.
- W2079450072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9710211" @default.
- W2079450072 hasPublicationYear "1998" @default.
- W2079450072 type Work @default.
- W2079450072 sameAs 2079450072 @default.
- W2079450072 citedByCount "192" @default.
- W2079450072 countsByYear W20794500722012 @default.
- W2079450072 countsByYear W20794500722013 @default.
- W2079450072 countsByYear W20794500722014 @default.
- W2079450072 countsByYear W20794500722015 @default.
- W2079450072 countsByYear W20794500722016 @default.
- W2079450072 countsByYear W20794500722017 @default.
- W2079450072 countsByYear W20794500722018 @default.
- W2079450072 countsByYear W20794500722019 @default.
- W2079450072 countsByYear W20794500722020 @default.
- W2079450072 countsByYear W20794500722022 @default.
- W2079450072 countsByYear W20794500722023 @default.
- W2079450072 crossrefType "journal-article" @default.
- W2079450072 hasAuthorship W2079450072A5016640976 @default.
- W2079450072 hasAuthorship W2079450072A5026527299 @default.
- W2079450072 hasAuthorship W2079450072A5063571876 @default.
- W2079450072 hasAuthorship W2079450072A5063904227 @default.
- W2079450072 hasAuthorship W2079450072A5065021872 @default.
- W2079450072 hasBestOaLocation W20794500721 @default.
- W2079450072 hasConcept C119524353 @default.
- W2079450072 hasConcept C12554922 @default.
- W2079450072 hasConcept C137738243 @default.
- W2079450072 hasConcept C141073059 @default.
- W2079450072 hasConcept C142669718 @default.
- W2079450072 hasConcept C1491633281 @default.
- W2079450072 hasConcept C151166631 @default.
- W2079450072 hasConcept C159985019 @default.
- W2079450072 hasConcept C189165786 @default.
- W2079450072 hasConcept C192562407 @default.
- W2079450072 hasConcept C195687474 @default.
- W2079450072 hasConcept C55493867 @default.
- W2079450072 hasConcept C62478195 @default.
- W2079450072 hasConcept C84416704 @default.
- W2079450072 hasConcept C85789140 @default.
- W2079450072 hasConcept C86803240 @default.
- W2079450072 hasConcept C95444343 @default.