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• W2079450433 abstract "Abstract —The ability of dopamine 1 (D 1 ) receptors to inhibit luminal Na + -H + exchanger (NHE) activity in renal proximal tubules and induce a natriuresis is impaired in spontaneously hypertensive rats (SHR). However, it is not clear whether the defect is at the level of the D 1 receptor, G sα , or effector proteins. The coupling of the D 1 receptor to G sα and NHE3 was studied in renal brush border membranes (BBM), devoid of cytoplasmic second messengers. D 1 receptor, G sα , and NHE3 expressions were similar in SHR and their normotensive controls, Wistar-Kyoto rats (WKY). Guanosine-5′- O -(3-thiotriphosphate) (GTPγS) decreased NHE activity and increased NHE3 linked with G sα similarly in WKY and SHR, indicating normal G sα and NHE3 regulation in SHR. However, D 1 agonists increased NHE3 linked with G sα in WKY but not in SHR, and the inhibitory effects of D 1 agonists on NHE activity were less in SHR than in WKY. Moreover, GTPγS enhanced the inhibitory effect of D 1 agonist on NHE activity in WKY but not in SHR, suggesting an uncoupling of the D 1 receptor from G sα /NHE3 in SHR. Similar results were obtained with the use of immortalized renal proximal tubule cells from WKY and SHR. We conclude that the defective D 1 receptor function in renal proximal tubules in SHR is proximal to G sα /effectors and presumably at the receptor level. The mechanism(s) responsible for the uncoupling of the D 1 receptor from G proteins remains to be determined. Because the primary structure of the D 1 receptor is not different between normotensive and hypertensive rats, differences in D 1 receptor posttranslational modification are possible." @default.
• W2079450433 created "2016-06-24" @default.
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• W2079450433 date "2000-09-01" @default.
• W2079450433 modified "2023-10-14" @default.
• W2079450433 title "Dopamine ₁ Receptor, G _sα , and Na ⁺ -H ⁺ Exchanger Interactions in the Kidney in Hypertension" @default.
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• W2079450433 doi "https://doi.org/10.1161/01.hyp.36.3.395" @default.
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