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• W2079450940 abstract "<b>Background:</b> Pulmonary fibrosis is a complex disease for which the predisposing genetic variants remain unknown. In a prior study, susceptibility to bleomycin induced pulmonary fibrosis was mapped to loci <i>Blmpf1</i> and <i>Blmpf2</i> on chromosomes 17 and 11, respectively, in a C57BL/6J (B6, susceptible) and C3Hf/KAM (C3H, resistant) mouse cross. <b>Methods:</b> Herein, the genetic basis of bleomycin induced pulmonary fibrosis was investigated in an approach combining gene expression and sequencing data with previously mapped linkage intervals. <b>Results:</b> In this study, gene expression analysis with microarrays revealed 1892 genes or ESTs (expressed sequence tags) to be differentially expressed between bleomycin treated B6 and C3H mice and 67 of these genetic elements map to <i>Blmpf1</i> or <i>Blmpf2</i>. This group included genes involved in an oxidative stress response, in apoptosis, and in immune regulation. A comparison of the B6 and C3H sequence, for <i>Blmpf1</i> and <i>Blmpf2</i>, made using the NCBI database and available C3H sequence, revealed approximately 35% of the genes in these regions contain non-synonymous coding sequence changes. An assessment of genotype/phenotype correlation among other inbred strains revealed 36% of these B6/C3H sequence variations predict for the known bleomycin induced fibrosis susceptibility of the DBA (susceptible) and A/J (resistant) mouse strains. <b>Conclusions:</b> Combining genomics approaches of differential gene expression and sequence variation potentially identifies approximately 5% the linked genes as fibrosis susceptibility candidate genes in this mouse cross." @default.
• W2079450940 created "2016-06-24" @default.
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• W2079450940 date "2005-06-01" @default.
• W2079450940 modified "2023-10-01" @default.
• W2079450940 title "Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions" @default.
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• W2079450940 doi "https://doi.org/10.1136/jmg.2004.027938" @default.
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