Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079450955> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2079450955 endingPage "102" @default.
- W2079450955 startingPage "98" @default.
- W2079450955 abstract "Our objective was to determine the frequency of allelic loss at 8p21 in sporadic epithelial ovarian cancer. We recently described allelic loss at this locus in 7/9 ovarian cancers from patients with BRCA1 gene mutations.We anonymously obtained and examined 40 unselected invasive epithelial ovarian cancers and 5 low-malignant-potential (LMP) ovarian tumors for loss of heterozygosity (LOH) at 8p12-22. Pure epithelial and stromal cell populations were procured selectively by laser capture microdissection and extracted DNA was amplified with polymorphic microsatellite markers spanning the region of interest.LOH was highest (50%) at marker D8S136 located at 8p21 with 15 of 30 informative cases exhibiting an allelic deletion. None of the LMP tumors evaluated showed LOH at 8p12-22. A trend toward more frequent LOH at 8p12-22 was identified with increasing disease aggressiveness from LMP to early stage invasive ovarian cancer to advanced stage invasive ovarian cancer (Lehman's test, P2 < 0.024).Fifty percent allelic loss at the distal portion of 8p21 has not been reported to date for sporadic epithelial ovarian carcinomas. The higher rate of loss in our cohort, in contrast to previous allelotyping studies, is due likely to analysis from homogenous cell populations. These results, in concert with our previous study of BRCA1 mutation-positive patients, suggest a tumor suppressor gene locus at 8p21 for epithelial ovarian cancer." @default.
- W2079450955 created "2016-06-24" @default.
- W2079450955 creator A5005621340 @default.
- W2079450955 creator A5013162996 @default.
- W2079450955 creator A5035477471 @default.
- W2079450955 creator A5038248146 @default.
- W2079450955 creator A5046446422 @default.
- W2079450955 creator A5054112793 @default.
- W2079450955 creator A5054146741 @default.
- W2079450955 date "1999-07-01" @default.
- W2079450955 modified "2023-10-16" @default.
- W2079450955 title "Allelic Loss on Chromosome Arm 8p: Analysis of Sporadic Epithelial Ovarian Tumors" @default.
- W2079450955 cites W1963667080 @default.
- W2079450955 cites W1968334977 @default.
- W2079450955 cites W1995472568 @default.
- W2079450955 cites W2013176158 @default.
- W2079450955 cites W2016102376 @default.
- W2079450955 cites W2016588422 @default.
- W2079450955 cites W2017387932 @default.
- W2079450955 cites W2036546668 @default.
- W2079450955 cites W2048404400 @default.
- W2079450955 cites W2059791006 @default.
- W2079450955 cites W2068776651 @default.
- W2079450955 cites W2079388655 @default.
- W2079450955 cites W2081422634 @default.
- W2079450955 cites W2109847775 @default.
- W2079450955 cites W2333258512 @default.
- W2079450955 doi "https://doi.org/10.1006/gyno.1999.5439" @default.
- W2079450955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10385558" @default.
- W2079450955 hasPublicationYear "1999" @default.
- W2079450955 type Work @default.
- W2079450955 sameAs 2079450955 @default.
- W2079450955 citedByCount "46" @default.
- W2079450955 countsByYear W20794509552014 @default.
- W2079450955 countsByYear W20794509552018 @default.
- W2079450955 countsByYear W20794509552019 @default.
- W2079450955 crossrefType "journal-article" @default.
- W2079450955 hasAuthorship W2079450955A5005621340 @default.
- W2079450955 hasAuthorship W2079450955A5013162996 @default.
- W2079450955 hasAuthorship W2079450955A5035477471 @default.
- W2079450955 hasAuthorship W2079450955A5038248146 @default.
- W2079450955 hasAuthorship W2079450955A5046446422 @default.
- W2079450955 hasAuthorship W2079450955A5054112793 @default.
- W2079450955 hasAuthorship W2079450955A5054146741 @default.
- W2079450955 hasConcept C104317684 @default.
- W2079450955 hasConcept C11242284 @default.
- W2079450955 hasConcept C121608353 @default.
- W2079450955 hasConcept C125965507 @default.
- W2079450955 hasConcept C142724271 @default.
- W2079450955 hasConcept C143589142 @default.
- W2079450955 hasConcept C150194340 @default.
- W2079450955 hasConcept C180754005 @default.
- W2079450955 hasConcept C2780427987 @default.
- W2079450955 hasConcept C3019054536 @default.
- W2079450955 hasConcept C502942594 @default.
- W2079450955 hasConcept C54355233 @default.
- W2079450955 hasConcept C71924100 @default.
- W2079450955 hasConcept C84597430 @default.
- W2079450955 hasConcept C86803240 @default.
- W2079450955 hasConceptScore W2079450955C104317684 @default.
- W2079450955 hasConceptScore W2079450955C11242284 @default.
- W2079450955 hasConceptScore W2079450955C121608353 @default.
- W2079450955 hasConceptScore W2079450955C125965507 @default.
- W2079450955 hasConceptScore W2079450955C142724271 @default.
- W2079450955 hasConceptScore W2079450955C143589142 @default.
- W2079450955 hasConceptScore W2079450955C150194340 @default.
- W2079450955 hasConceptScore W2079450955C180754005 @default.
- W2079450955 hasConceptScore W2079450955C2780427987 @default.
- W2079450955 hasConceptScore W2079450955C3019054536 @default.
- W2079450955 hasConceptScore W2079450955C502942594 @default.
- W2079450955 hasConceptScore W2079450955C54355233 @default.
- W2079450955 hasConceptScore W2079450955C71924100 @default.
- W2079450955 hasConceptScore W2079450955C84597430 @default.
- W2079450955 hasConceptScore W2079450955C86803240 @default.
- W2079450955 hasIssue "1" @default.
- W2079450955 hasLocation W20794509551 @default.
- W2079450955 hasLocation W20794509552 @default.
- W2079450955 hasOpenAccess W2079450955 @default.
- W2079450955 hasPrimaryLocation W20794509551 @default.
- W2079450955 hasRelatedWork W1981216920 @default.
- W2079450955 hasRelatedWork W2002535047 @default.
- W2079450955 hasRelatedWork W2066522272 @default.
- W2079450955 hasRelatedWork W2372446483 @default.
- W2079450955 hasRelatedWork W2382515652 @default.
- W2079450955 hasRelatedWork W2408176339 @default.
- W2079450955 hasRelatedWork W2415197309 @default.
- W2079450955 hasRelatedWork W2416744961 @default.
- W2079450955 hasRelatedWork W2417158027 @default.
- W2079450955 hasRelatedWork W3080792583 @default.
- W2079450955 hasVolume "74" @default.
- W2079450955 isParatext "false" @default.
- W2079450955 isRetracted "false" @default.
- W2079450955 magId "2079450955" @default.
- W2079450955 workType "article" @default.