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- W2079453086 abstract "The purpose of this study was to assess 65 pedigrees ascertained through a Bipolar I (BPI) proband for evidence of linkage, using nonparametric methods in a genome-wide scan and for possible parent of origin effect using several analytical methods. We identified 15 loci with nominally significant evidence for increased allele sharing among affected relative pairs. Eight of these regions, at 8q24, 18q22, 4q32, 13q12, 4q35, 10q26, 2p12, and 12q24, directly overlap with previously reported evidence of linkage to bipolar disorder. Five regions at 20p13, 2p22, 14q23, 9p13, and 1q41 are within several Mb of previously reported regions. We report our findings in rank order and the top five markers had an NPL>2.5. The peak finding in these regions were D8S256 at 8q24, NPL 3.13; D18S878 at 18q22, NPL 2.90; D4S1629 at 4q32, NPL 2.80; D2S99 at 2p12, NPL 2.54; and D13S1493 at 13q12, NPL 2.53. No locus produced statistically significant evidence for linkage at the genome-wide level. The parent of origin effect was studied and consistent with our previous findings, evidence for a locus on 18q22 was predominantly from families wherein the father or paternal lineage was affected. There was evidence consistent with paternal imprinting at the loci on 13q12 and 1q41." @default.
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- W2079453086 date "2003-03-01" @default.
- W2079453086 modified "2023-10-18" @default.
- W2079453086 title "Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12" @default.
- W2079453086 cites W1498011243 @default.
- W2079453086 cites W1939097681 @default.
- W2079453086 cites W1974175508 @default.
- W2079453086 cites W1974702488 @default.
- W2079453086 cites W1976741643 @default.
- W2079453086 cites W1977265864 @default.
- W2079453086 cites W1981720975 @default.
- W2079453086 cites W1983475782 @default.
- W2079453086 cites W1994221025 @default.
- W2079453086 cites W1996747785 @default.
- W2079453086 cites W1997190651 @default.
- W2079453086 cites W1998158007 @default.
- W2079453086 cites W2001091544 @default.
- W2079453086 cites W2001189997 @default.
- W2079453086 cites W2003491970 @default.
- W2079453086 cites W2012944128 @default.
- W2079453086 cites W2014949652 @default.
- W2079453086 cites W2016708122 @default.
- W2079453086 cites W2017428806 @default.
- W2079453086 cites W2017923612 @default.
- W2079453086 cites W2018131844 @default.
- W2079453086 cites W2020922467 @default.
- W2079453086 cites W2025830166 @default.
- W2079453086 cites W2035897560 @default.
- W2079453086 cites W2038424717 @default.
- W2079453086 cites W2040160614 @default.
- W2079453086 cites W2043296500 @default.
- W2079453086 cites W2044461300 @default.
- W2079453086 cites W2045482123 @default.
- W2079453086 cites W2049787467 @default.
- W2079453086 cites W2050124261 @default.
- W2079453086 cites W2050160433 @default.
- W2079453086 cites W2056572328 @default.
- W2079453086 cites W2063473805 @default.
- W2079453086 cites W2064480919 @default.
- W2079453086 cites W2065979337 @default.
- W2079453086 cites W2066920376 @default.
- W2079453086 cites W2068725139 @default.
- W2079453086 cites W2069395420 @default.
- W2079453086 cites W2070954442 @default.
- W2079453086 cites W2071838879 @default.
- W2079453086 cites W2076710798 @default.
- W2079453086 cites W2080073436 @default.
- W2079453086 cites W2081345663 @default.
- W2079453086 cites W2082656717 @default.
- W2079453086 cites W2083471180 @default.
- W2079453086 cites W2087200653 @default.
- W2079453086 cites W2101464192 @default.
- W2079453086 cites W2105257553 @default.
- W2079453086 cites W2105392835 @default.
- W2079453086 cites W2108388704 @default.
- W2079453086 cites W2113779935 @default.
- W2079453086 cites W2115689722 @default.
- W2079453086 cites W2116314953 @default.
- W2079453086 cites W2116628662 @default.
- W2079453086 cites W2117703098 @default.
- W2079453086 cites W2118109089 @default.
- W2079453086 cites W2123333307 @default.
- W2079453086 cites W2124525743 @default.
- W2079453086 cites W2126436885 @default.
- W2079453086 cites W2127424588 @default.
- W2079453086 cites W2142207806 @default.
- W2079453086 cites W2144502213 @default.
- W2079453086 cites W2146429339 @default.
- W2079453086 cites W2147017267 @default.
- W2079453086 cites W2148480046 @default.
- W2079453086 cites W2155430431 @default.
- W2079453086 cites W2164562866 @default.