FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079457673> ?p ?o ?g. }

• W2079457673 endingPage "1545" @default.
• W2079457673 startingPage "1535" @default.
• W2079457673 abstract "Supercritical fluid chromatography (SFC) provides a number of advantages over traditional HPLC such as speed, practical use of longer columns, a normal-phase retention mechanism, and reduced use of organic solvents. Yet, it has been a technique traditionally limited to relatively nonpolar compounds. The nature of SFC mobile and stationary phases did not allow the elution of ionic compounds or of peptides, except, in the latter case, for the most hydrophobic peptides. The characterization of peptides is critically important for drug discovery and development in the pharmaceutical industry, as well as for a variety of other important applications. Here, for the first time to our knowledge, we show that relatively large peptides (at least 40 mers), containing a variety of acidic and basic residues, can be eluted in SFC. We used trifluoroacetic acid as additive in a CO2/methanol mobile phase to suppress deprotonation of peptide carboxylic acid groups and to protonate peptide amino groups. A 2-ethylpyridine bonded silica column, which was specifically developed for SFC, was used for the majority of this work. The relatively simple mobile phase was compatible with mass spectrometric detection." @default.
• W2079457673 created "2016-06-24" @default.
• W2079457673 creator A5015268941 @default.
• W2079457673 creator A5019468821 @default.
• W2079457673 creator A5050182135 @default.
• W2079457673 creator A5076459544 @default.
• W2079457673 date "2006-01-31" @default.
• W2079457673 modified "2023-10-16" @default.
• W2079457673 title "Feasibility of Supercritical Fluid Chromatography/Mass Spectrometry of Polypeptides with Up to 40-Mers" @default.
• W2079457673 cites W1967708826 @default.
• W2079457673 cites W1977600766 @default.
• W2079457673 cites W2002033681 @default.
• W2079457673 cites W2021378643 @default.
• W2079457673 cites W2022246419 @default.
• W2079457673 cites W2033967027 @default.
• W2079457673 cites W2035889653 @default.
• W2079457673 cites W2036730681 @default.
• W2079457673 cites W2041977973 @default.
• W2079457673 cites W2045123283 @default.
• W2079457673 cites W2057260895 @default.
• W2079457673 cites W2063859419 @default.
• W2079457673 cites W2079578217 @default.
• W2079457673 cites W2085068396 @default.
• W2079457673 cites W2088424996 @default.
• W2079457673 cites W2125287536 @default.
• W2079457673 cites W2547496768 @default.
• W2079457673 doi "https://doi.org/10.1021/ac052025s" @default.
• W2079457673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16503605" @default.
• W2079457673 hasPublicationYear "2006" @default.
• W2079457673 type Work @default.
• W2079457673 sameAs 2079457673 @default.
• W2079457673 citedByCount "77" @default.
• W2079457673 countsByYear W20794576732012 @default.
• W2079457673 countsByYear W20794576732013 @default.
• W2079457673 countsByYear W20794576732014 @default.
• W2079457673 countsByYear W20794576732015 @default.
• W2079457673 countsByYear W20794576732016 @default.
• W2079457673 countsByYear W20794576732017 @default.
• W2079457673 countsByYear W20794576732018 @default.
• W2079457673 countsByYear W20794576732019 @default.
• W2079457673 countsByYear W20794576732020 @default.
• W2079457673 countsByYear W20794576732021 @default.
• W2079457673 countsByYear W20794576732022 @default.
• W2079457673 countsByYear W20794576732023 @default.
• W2079457673 crossrefType "journal-article" @default.
• W2079457673 hasAuthorship W2079457673A5015268941 @default.
• W2079457673 hasAuthorship W2079457673A5019468821 @default.
• W2079457673 hasAuthorship W2079457673A5050182135 @default.
• W2079457673 hasAuthorship W2079457673A5076459544 @default.
• W2079457673 hasConcept C118419359 @default.
• W2079457673 hasConcept C118629725 @default.
• W2079457673 hasConcept C145148216 @default.
• W2079457673 hasConcept C162356407 @default.
• W2079457673 hasConcept C178790620 @default.
• W2079457673 hasConcept C179998833 @default.
• W2079457673 hasConcept C185592680 @default.
• W2079457673 hasConcept C203147553 @default.
• W2079457673 hasConcept C21951064 @default.
• W2079457673 hasConcept C2779281246 @default.
• W2079457673 hasConcept C2779607525 @default.
• W2079457673 hasConcept C2780112151 @default.
• W2079457673 hasConcept C43617362 @default.
• W2079457673 hasConcept C44280652 @default.
• W2079457673 hasConcept C55493867 @default.
• W2079457673 hasConcept C73826308 @default.
• W2079457673 hasConceptScore W2079457673C118419359 @default.
• W2079457673 hasConceptScore W2079457673C118629725 @default.
• W2079457673 hasConceptScore W2079457673C145148216 @default.
• W2079457673 hasConceptScore W2079457673C162356407 @default.
• W2079457673 hasConceptScore W2079457673C178790620 @default.
• W2079457673 hasConceptScore W2079457673C179998833 @default.
• W2079457673 hasConceptScore W2079457673C185592680 @default.
• W2079457673 hasConceptScore W2079457673C203147553 @default.
• W2079457673 hasConceptScore W2079457673C21951064 @default.
• W2079457673 hasConceptScore W2079457673C2779281246 @default.
• W2079457673 hasConceptScore W2079457673C2779607525 @default.
• W2079457673 hasConceptScore W2079457673C2780112151 @default.
• W2079457673 hasConceptScore W2079457673C43617362 @default.
• W2079457673 hasConceptScore W2079457673C44280652 @default.
• W2079457673 hasConceptScore W2079457673C55493867 @default.
• W2079457673 hasConceptScore W2079457673C73826308 @default.
• W2079457673 hasIssue "5" @default.
• W2079457673 hasLocation W20794576731 @default.
• W2079457673 hasLocation W20794576732 @default.
• W2079457673 hasOpenAccess W2079457673 @default.
• W2079457673 hasPrimaryLocation W20794576731 @default.
• W2079457673 hasRelatedWork W1988192344 @default.
• W2079457673 hasRelatedWork W2010468191 @default.
• W2079457673 hasRelatedWork W2023061898 @default.
• W2079457673 hasRelatedWork W2033281412 @default.
• W2079457673 hasRelatedWork W2037171905 @default.
• W2079457673 hasRelatedWork W2051351267 @default.
• W2079457673 hasRelatedWork W2070267312 @default.
• W2079457673 hasRelatedWork W2084348824 @default.
• W2079457673 hasRelatedWork W2107172911 @default.
• W2079457673 hasRelatedWork W2388855331 @default.
• W2079457673 hasVolume "78" @default.
• W2079457673 isParatext "false" @default.

• next