FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079458064> ?p ?o ?g. }

• W2079458064 endingPage "3538" @default.
• W2079458064 startingPage "3531" @default.
• W2079458064 abstract "A prototypic hammerhead ribozyme has three helices that surround an asymmetrical central core loop. We have mutagenized a hammerhead type ribozyme. In agreement with previous studies, progressive removal of stem-loop II from a three stemmed ribozyme showed that this region is not absolutely critical for catalysis. However, complete elimination of stem II and its loop did reduce, but did not eliminate, function. In a stem-loop II-deleted ribozyme, activity was best preserved when a purine, preferably a G, was present at position 10.1. This G contributed to catalysis irregardless of its role as either one part of a canonical pair with a C residue at 11.1 or a lone nucleotide with C (11.1) deleted. Computational methods using lattices generated 87 million three-dimensional chain forms for a stem-loop II-deleted RNA complex that preserved one potential G.C base pair at positions 10.1 and 11.1. This exhaustive set of chain forms included one major class of structures with G(10.1) being spatially proximal to the GUCX cleavage site of the substrate strand. Strong correlations were observed between colinear arrangement of stems I and III, constraints of base-pairing in the central core loop, and one particular placement of G(10.1) relative to the cleavage site. Our calculations of a stem-loop II-deleted ribozyme indicate that without needing to invoke any other constraints, the inherent asymmetry in the lengths of the two loop strands (3 nt in one and 7 nt in the other) that compose the core and flank G10.1-C11.1 stipulated strongly this particular G placement. This suggests that the hammerhead ribozyme maintains an asymmetry in its internal loop for a necessary structure/function reason." @default.
• W2079458064 created "2016-06-24" @default.
• W2079458064 creator A5014084212 @default.
• W2079458064 creator A5023494109 @default.
• W2079458064 creator A5025168014 @default.
• W2079458064 creator A5077051203 @default.
• W2079458064 creator A5080524336 @default.
• W2079458064 date "1995-01-01" @default.
• W2079458064 modified "2023-10-14" @default.
• W2079458064 title "A small modified hammerhead ribozyme and its conformational characteristics determined by mutagenesis and lattice calculation" @default.
• W2079458064 cites W1464311349 @default.
• W2079458064 cites W1569560802 @default.
• W2079458064 cites W1962582496 @default.
• W2079458064 cites W1966105091 @default.
• W2079458064 cites W1977335029 @default.
• W2079458064 cites W1986232581 @default.
• W2079458064 cites W1988989917 @default.
• W2079458064 cites W1991097591 @default.
• W2079458064 cites W1999443162 @default.
• W2079458064 cites W2002048308 @default.
• W2079458064 cites W2003049655 @default.
• W2079458064 cites W2011823197 @default.
• W2079458064 cites W2020552066 @default.
• W2079458064 cites W2028099075 @default.
• W2079458064 cites W2031266357 @default.
• W2079458064 cites W2035783320 @default.
• W2079458064 cites W2039326418 @default.
• W2079458064 cites W2057183734 @default.
• W2079458064 cites W2057702331 @default.
• W2079458064 cites W2066547504 @default.
• W2079458064 cites W2072325285 @default.
• W2079458064 cites W2073263035 @default.
• W2079458064 cites W2077799438 @default.
• W2079458064 cites W2081125994 @default.
• W2079458064 cites W2082607200 @default.
• W2079458064 cites W2083510837 @default.
• W2079458064 cites W2092409871 @default.
• W2079458064 cites W2134249188 @default.
• W2079458064 cites W2149386752 @default.
• W2079458064 cites W2163414819 @default.
• W2079458064 cites W2169190177 @default.
• W2079458064 cites W2180204534 @default.
• W2079458064 doi "https://doi.org/10.1093/nar/23.17.3531" @default.
• W2079458064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/307234" @default.
• W2079458064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7567466" @default.
• W2079458064 hasPublicationYear "1995" @default.
• W2079458064 type Work @default.
• W2079458064 sameAs 2079458064 @default.
• W2079458064 citedByCount "6" @default.
• W2079458064 crossrefType "journal-article" @default.
• W2079458064 hasAuthorship W2079458064A5014084212 @default.
• W2079458064 hasAuthorship W2079458064A5023494109 @default.
• W2079458064 hasAuthorship W2079458064A5025168014 @default.
• W2079458064 hasAuthorship W2079458064A5077051203 @default.
• W2079458064 hasAuthorship W2079458064A5080524336 @default.
• W2079458064 hasBestOaLocation W20794580642 @default.
• W2079458064 hasConcept C104317684 @default.
• W2079458064 hasConcept C105130999 @default.
• W2079458064 hasConcept C107745601 @default.
• W2079458064 hasConcept C1342335 @default.
• W2079458064 hasConcept C151730666 @default.
• W2079458064 hasConcept C169663058 @default.
• W2079458064 hasConcept C175156509 @default.
• W2079458064 hasConcept C185581394 @default.
• W2079458064 hasConcept C185592680 @default.
• W2079458064 hasConcept C2779792011 @default.
• W2079458064 hasConcept C30951146 @default.
• W2079458064 hasConcept C43369102 @default.
• W2079458064 hasConcept C54355233 @default.
• W2079458064 hasConcept C552990157 @default.
• W2079458064 hasConcept C66144319 @default.
• W2079458064 hasConcept C67705224 @default.
• W2079458064 hasConcept C71240020 @default.
• W2079458064 hasConcept C76346623 @default.
• W2079458064 hasConcept C86803240 @default.
• W2079458064 hasConceptScore W2079458064C104317684 @default.
• W2079458064 hasConceptScore W2079458064C105130999 @default.
• W2079458064 hasConceptScore W2079458064C107745601 @default.
• W2079458064 hasConceptScore W2079458064C1342335 @default.
• W2079458064 hasConceptScore W2079458064C151730666 @default.
• W2079458064 hasConceptScore W2079458064C169663058 @default.
• W2079458064 hasConceptScore W2079458064C175156509 @default.
• W2079458064 hasConceptScore W2079458064C185581394 @default.
• W2079458064 hasConceptScore W2079458064C185592680 @default.
• W2079458064 hasConceptScore W2079458064C2779792011 @default.
• W2079458064 hasConceptScore W2079458064C30951146 @default.
• W2079458064 hasConceptScore W2079458064C43369102 @default.
• W2079458064 hasConceptScore W2079458064C54355233 @default.
• W2079458064 hasConceptScore W2079458064C552990157 @default.
• W2079458064 hasConceptScore W2079458064C66144319 @default.
• W2079458064 hasConceptScore W2079458064C67705224 @default.
• W2079458064 hasConceptScore W2079458064C71240020 @default.
• W2079458064 hasConceptScore W2079458064C76346623 @default.
• W2079458064 hasConceptScore W2079458064C86803240 @default.
• W2079458064 hasIssue "17" @default.
• W2079458064 hasLocation W20794580641 @default.
• W2079458064 hasLocation W20794580642 @default.
• W2079458064 hasLocation W20794580643 @default.

• next