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- W2079459081 abstract "Computation of morbidity and mortality from data published from a double blind placebo-controlled trial of vitamin A given in 0 1 or 2 doses to Indian children under 5 by village workers results in unexplained variation in morbidity reports. Morbidity was assessed by field workers who distributed vitamin A emphasizing diarrhea respiratory infection and measles in groups of 7691 children given vitamin A vs. 8084 given placebos. Placebo reduced the prevalence of night blindness and Bitots spots from 6-2.9%. Morbidity was significantly different at the baseline 65% in the treated group vs. 72% in the placebo group (p=<0.005). After 1 dose morbidity rose to 87% in the treated group but remained 72% in placebo treated children. After 2 doses morbidity rose to 99% of the vitamin treated group and 98% in the placebo group. It is not clear in the report whether ill children were referred to the clinic given management information or no intervention. In any case contact with village workers improved mortality from 17.6/1000 to 2.3/1000 in the vitamin A group and from 17.2/1000 to 2.2/1000 in the placebo group. These striking results from mere contact with health workers suggest an effective way to reduce mortality in children under 5 in developing countries." @default.
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- W2079459081 date "1991-04-01" @default.
- W2079459081 modified "2023-09-24" @default.
- W2079459081 title "Effect of massive dose vitamin A on morbidity and mortality in Indian children" @default.
- W2079459081 doi "https://doi.org/10.1016/0140-6736(91)92554-f" @default.
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