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• W2079459227 abstract "Kashin-Beck Disease (KBD) is an endemic, chronic and degenerative osteoarthropathy principally occurring in children. The characteristic pathological change of KBD is chondrocyte necrosis in hyaline articular cartilage. Proteoglycans are one of the major components in the extracellular matrix of articular cartilage, and disrupted proteoglycan metabolism and loss of proteoglycans in articular cartilage from KBD patients has been observed. In this mini-review, we discuss the close relationship between chondrocyte death including necrosis and loss of proteoglycan, and its potential mechanism during KBD onset and development, which may provide new clues for KBD research." @default.
• W2079459227 created "2016-06-24" @default.
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• W2079459227 date "2012-06-26" @default.
• W2079459227 modified "2023-09-27" @default.
• W2079459227 title "Proteoglycan metabolism, cell death and Kashin-Beck Disease" @default.
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• W2079459227 doi "https://doi.org/10.1007/s10719-012-9421-2" @default.
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