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- W2079461170 abstract "A combination of gamma scintigraphy and pharmacokinctic analysis has been used to investigate whether the variable effect of food on bioavailability of rifampicin could be attributed to lymphatic absorption or to alteration of the gastrointestinal transit time of the drug. Seven healthy subjects participated in the study and were given a 99mTc-labelled meal and two rifampicin capsules containing 111 In-labelled resin and the gastrointestinal transit of both labels was measured. Rifampicin levels were measured in plasma by HPLC. Increasing the fat content of the meal did not alter the gastric emptying of the meal or the resin (T50 emptying = 2.99 h low fat meal, 5.83 h high fat meal; T50 = 3.14 h resin low fat meal, 2.70 h high fat meal), but it did significantly delay the time for the meal to reach the colon T50 arrival = 9.11 h low fat meal, 10.99 h high fat meal). Surprisingly it did not affect the arrival time of the co-administered indium-labelled resin (T50 arrival = 8.91 h low fat meal, 8.43 h high fat meal). The increased fat present in the meal did not alter the pharmacokinetic parameters for rifampicin." @default.
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- W2079461170 date "1994-08-01" @default.
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- W2079461170 title "The effect of high and low fat meals on the absorption of rifampicin from the gastrointestinal tract in volunteer subjects" @default.
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- W2079461170 doi "https://doi.org/10.1016/0378-5173(94)90323-9" @default.
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