Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079461434> ?p ?o ?g. }
- W2079461434 endingPage "1035" @default.
- W2079461434 startingPage "1025" @default.
- W2079461434 abstract "Tsetse flies (Glossina sp.) are blood-feeding dipteran insects that transmit African trypanosomes, parasites that are responsible for human sleeping sickness and veterinary infections. Increasing attention is being paid to the effects of tsetse fly saliva deposited at the feeding site, which enables the blood-feeding process and putatively promotes parasite transmission. Here we demonstrate that saliva induces strong humoral responses against the major 43-45 kDa protein fraction (tsetse salivary gland proteins 1 and 2 - Tsal1 and Tsal2) in mice and humans and suppresses murine T and B cell responses to heterologous antigen. The saliva-induced immune response is associated with a Th2-biased cytokine profile and the production of mainly IgG1 and IgE antibody isotypes. Functionally, the antibodies raised in mice exposed to tsetse fly bites or induced after experimental saliva immunisation do not affect the fly's blood-feeding efficiency nor its survival. We propose that anti-saliva as well as anti-Tsal1/2 antibody responses can be used in epidemiological studies as a tool to analyze human exposure to tsetse flies." @default.
- W2079461434 created "2016-06-24" @default.
- W2079461434 creator A5035905258 @default.
- W2079461434 creator A5044978830 @default.
- W2079461434 creator A5054540312 @default.
- W2079461434 creator A5064901452 @default.
- W2079461434 creator A5072435087 @default.
- W2079461434 creator A5090967339 @default.
- W2079461434 date "2006-08-01" @default.
- W2079461434 modified "2023-10-14" @default.
- W2079461434 title "Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessment" @default.
- W2079461434 cites W1506430118 @default.
- W2079461434 cites W1640779052 @default.
- W2079461434 cites W1848405388 @default.
- W2079461434 cites W1976521369 @default.
- W2079461434 cites W1976825859 @default.
- W2079461434 cites W1979514172 @default.
- W2079461434 cites W1982375817 @default.
- W2079461434 cites W1985812450 @default.
- W2079461434 cites W1990702040 @default.
- W2079461434 cites W1990748978 @default.
- W2079461434 cites W2002155819 @default.
- W2079461434 cites W2009172136 @default.
- W2079461434 cites W2015564062 @default.
- W2079461434 cites W2033239404 @default.
- W2079461434 cites W2034227238 @default.
- W2079461434 cites W2038533031 @default.
- W2079461434 cites W2042072042 @default.
- W2079461434 cites W2042616736 @default.
- W2079461434 cites W2048717576 @default.
- W2079461434 cites W2049281893 @default.
- W2079461434 cites W2056859114 @default.
- W2079461434 cites W2067118713 @default.
- W2079461434 cites W2080092897 @default.
- W2079461434 cites W2089677648 @default.
- W2079461434 cites W2092982688 @default.
- W2079461434 cites W2096424360 @default.
- W2079461434 cites W2097242695 @default.
- W2079461434 cites W2098259439 @default.
- W2079461434 cites W2100699905 @default.
- W2079461434 cites W2101108802 @default.
- W2079461434 cites W2101472580 @default.
- W2079461434 cites W2103933383 @default.
- W2079461434 cites W2104643105 @default.
- W2079461434 cites W2110838514 @default.
- W2079461434 cites W2112223021 @default.
- W2079461434 cites W2118947750 @default.
- W2079461434 cites W2120112111 @default.
- W2079461434 cites W2120365747 @default.
- W2079461434 cites W2121772767 @default.
- W2079461434 cites W2126755258 @default.
- W2079461434 cites W2129183958 @default.
- W2079461434 cites W2135377168 @default.
- W2079461434 cites W2139882542 @default.
- W2079461434 cites W2141895910 @default.
- W2079461434 cites W2143488564 @default.
- W2079461434 cites W2150815514 @default.
- W2079461434 cites W2152623605 @default.
- W2079461434 cites W2160984918 @default.
- W2079461434 cites W2313538296 @default.
- W2079461434 cites W2394800215 @default.
- W2079461434 cites W2416067240 @default.
- W2079461434 cites W2416956981 @default.
- W2079461434 cites W2464287200 @default.
- W2079461434 cites W55117266 @default.
- W2079461434 doi "https://doi.org/10.1016/j.ijpara.2006.05.002" @default.
- W2079461434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16777113" @default.
- W2079461434 hasPublicationYear "2006" @default.
- W2079461434 type Work @default.
- W2079461434 sameAs 2079461434 @default.
- W2079461434 citedByCount "47" @default.
- W2079461434 countsByYear W20794614342012 @default.
- W2079461434 countsByYear W20794614342013 @default.
- W2079461434 countsByYear W20794614342014 @default.
- W2079461434 countsByYear W20794614342015 @default.
- W2079461434 countsByYear W20794614342016 @default.
- W2079461434 countsByYear W20794614342017 @default.
- W2079461434 countsByYear W20794614342018 @default.
- W2079461434 countsByYear W20794614342019 @default.
- W2079461434 countsByYear W20794614342020 @default.
- W2079461434 countsByYear W20794614342021 @default.
- W2079461434 countsByYear W20794614342022 @default.
- W2079461434 countsByYear W20794614342023 @default.
- W2079461434 crossrefType "journal-article" @default.
- W2079461434 hasAuthorship W2079461434A5035905258 @default.
- W2079461434 hasAuthorship W2079461434A5044978830 @default.
- W2079461434 hasAuthorship W2079461434A5054540312 @default.
- W2079461434 hasAuthorship W2079461434A5064901452 @default.
- W2079461434 hasAuthorship W2079461434A5072435087 @default.
- W2079461434 hasAuthorship W2079461434A5090967339 @default.
- W2079461434 hasConcept C104317684 @default.
- W2079461434 hasConcept C141105273 @default.
- W2079461434 hasConcept C147483822 @default.
- W2079461434 hasConcept C159047783 @default.
- W2079461434 hasConcept C159654299 @default.
- W2079461434 hasConcept C18903297 @default.
- W2079461434 hasConcept C203014093 @default.
- W2079461434 hasConcept C2777229581 @default.