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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079461641> ?p ?o ?g. }

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• W2079461641 abstract "An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a cross metathesis strategy for the side chain synthesis." @default.
• W2079461641 created "2016-06-24" @default.
• W2079461641 creator A5026749613 @default.
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• W2079461641 date "2012-09-06" @default.
• W2079461641 modified "2023-10-09" @default.
• W2079461641 title "Enantioselective Total Synthesis of Pladienolide B: A Potent Spliceosome Inhibitor" @default.
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• W2079461641 doi "https://doi.org/10.1021/ol301886g" @default.
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