FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079462331> ?p ?o ?g. }

• W2079462331 endingPage "916" @default.
• W2079462331 startingPage "908" @default.
• W2079462331 abstract "An understanding of cellular processes that determine the response to ionizing radiation (IR) exposure is essential to improve radiotherapy and to assess risks to human health after accidental radiation exposure. Exposure to IR induces a multitude of biological effects. Recent studies have indicated the involvement of epigenetic events in regulating the responses of irradiated cells. DNA methylation, where the cytosine bases in CpG dimers are converted to 5-methyl cytosine, is an epigenetic event that has been shown to regulate a variety of biological processes. We investigated the DNA methylation changes in irradiated TK6 and WTK1 human cells that differ in sensitivity to IR. The global DNA methylation alterations as measured by an enzyme-linked immunosorbent assay-based assay showed hypomethylation in both type of cells. Using an arbitrarily primed polymerase chain reaction (AP-PCR) approach, we observed time-dependent dynamic changes in the regional genomic DNA methylation patterns in both cell lines. The AP-PCR DNA methylation profiles were different between TK6 and WTK1 cells, indicating the involvement of differential genomic DNA responses to radiation treatment. The analysis of the components of the DNA methylation machinery showed the modulation of maintenance and de novo methyltransferases in irradiated cells. DNMT1 mRNA levels were increased in TK6 cells after irradiation but were repressed in WTK1 cells. DNMT3A and DNMT3B were induced in both cells after radiation treatment. TET1, involved in the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), was induced in both cells. This study demonstrates that irradiated cells acquire epigenetic changes in the DNA methylation patterns, and the associated cellular machinery are involved in the response to radiation exposure. This study also shows that DNA methylation patterns change at different genomic regions and are dependent on time after irradiation and the genetic background of the cell." @default.
• W2079462331 created "2016-06-24" @default.
• W2079462331 creator A5037125377 @default.
• W2079462331 creator A5056265823 @default.
• W2079462331 date "2012-06-01" @default.
• W2079462331 modified "2023-09-25" @default.
• W2079462331 title "Differential DNA Methylation Alterations in Radiation-Sensitive and -Resistant Cells" @default.
• W2079462331 cites W1481035150 @default.
• W2079462331 cites W1555479734 @default.
• W2079462331 cites W1964556975 @default.
• W2079462331 cites W1972636714 @default.
• W2079462331 cites W1975227141 @default.
• W2079462331 cites W1976506743 @default.
• W2079462331 cites W1978516662 @default.
• W2079462331 cites W1979273476 @default.
• W2079462331 cites W1980655006 @default.
• W2079462331 cites W1981095724 @default.
• W2079462331 cites W1982854339 @default.
• W2079462331 cites W1989416640 @default.
• W2079462331 cites W1994465394 @default.
• W2079462331 cites W2007201884 @default.
• W2079462331 cites W2009303494 @default.
• W2079462331 cites W2012782052 @default.
• W2079462331 cites W2018339172 @default.
• W2079462331 cites W2018358395 @default.
• W2079462331 cites W2022556336 @default.
• W2079462331 cites W2029868343 @default.
• W2079462331 cites W2030283142 @default.
• W2079462331 cites W2048074675 @default.
• W2079462331 cites W2050788633 @default.
• W2079462331 cites W2053213384 @default.
• W2079462331 cites W2053856666 @default.
• W2079462331 cites W2055726926 @default.
• W2079462331 cites W2059819773 @default.
• W2079462331 cites W2069150999 @default.
• W2079462331 cites W2069288310 @default.
• W2079462331 cites W2078581194 @default.
• W2079462331 cites W2088930918 @default.
• W2079462331 cites W2103405053 @default.
• W2079462331 cites W2107277218 @default.
• W2079462331 cites W2108664872 @default.
• W2079462331 cites W2111131204 @default.
• W2079462331 cites W2121118054 @default.
• W2079462331 cites W2121417064 @default.
• W2079462331 cites W2126475135 @default.
• W2079462331 cites W2135886487 @default.
• W2079462331 cites W2152451432 @default.
• W2079462331 cites W2152896792 @default.
• W2079462331 cites W2171730570 @default.
• W2079462331 cites W2321499923 @default.
• W2079462331 cites W2325837033 @default.
• W2079462331 cites W2337234078 @default.
• W2079462331 cites W4230580872 @default.
• W2079462331 cites W4252103103 @default.
• W2079462331 doi "https://doi.org/10.1089/dna.2011.1509" @default.
• W2079462331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22185261" @default.
• W2079462331 hasPublicationYear "2012" @default.
• W2079462331 type Work @default.
• W2079462331 sameAs 2079462331 @default.
• W2079462331 citedByCount "47" @default.
• W2079462331 countsByYear W20794623312012 @default.
• W2079462331 countsByYear W20794623312013 @default.
• W2079462331 countsByYear W20794623312014 @default.
• W2079462331 countsByYear W20794623312015 @default.
• W2079462331 countsByYear W20794623312016 @default.
• W2079462331 countsByYear W20794623312017 @default.
• W2079462331 countsByYear W20794623312018 @default.
• W2079462331 countsByYear W20794623312019 @default.
• W2079462331 countsByYear W20794623312020 @default.
• W2079462331 countsByYear W20794623312021 @default.
• W2079462331 countsByYear W20794623312022 @default.
• W2079462331 countsByYear W20794623312023 @default.
• W2079462331 crossrefType "journal-article" @default.
• W2079462331 hasAuthorship W2079462331A5037125377 @default.
• W2079462331 hasAuthorship W2079462331A5056265823 @default.
• W2079462331 hasConcept C104317684 @default.
• W2079462331 hasConcept C140173407 @default.
• W2079462331 hasConcept C150194340 @default.
• W2079462331 hasConcept C153911025 @default.
• W2079462331 hasConcept C175211621 @default.
• W2079462331 hasConcept C190727270 @default.
• W2079462331 hasConcept C2779979206 @default.
• W2079462331 hasConcept C33288867 @default.
• W2079462331 hasConcept C41091548 @default.
• W2079462331 hasConcept C54355233 @default.
• W2079462331 hasConcept C552990157 @default.
• W2079462331 hasConcept C86803240 @default.
• W2079462331 hasConcept C91965660 @default.
• W2079462331 hasConceptScore W2079462331C104317684 @default.
• W2079462331 hasConceptScore W2079462331C140173407 @default.
• W2079462331 hasConceptScore W2079462331C150194340 @default.
• W2079462331 hasConceptScore W2079462331C153911025 @default.
• W2079462331 hasConceptScore W2079462331C175211621 @default.
• W2079462331 hasConceptScore W2079462331C190727270 @default.
• W2079462331 hasConceptScore W2079462331C2779979206 @default.
• W2079462331 hasConceptScore W2079462331C33288867 @default.
• W2079462331 hasConceptScore W2079462331C41091548 @default.
• W2079462331 hasConceptScore W2079462331C54355233 @default.

• next