FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079466437> ?p ?o ?g. }

• W2079466437 endingPage "C714" @default.
• W2079466437 startingPage "C707" @default.
• W2079466437 abstract "Adhesive interactions between monocytes and vascular smooth muscle cells (VSMC) may contribute to subendothelial monocyte-macrophage retention in atherosclerosis. We investigated the effects of angiotensin II (ANG II) and platelet-derived growth factor (PDGF)-BB on VSMC-monocyte interactions. Treatment of human aortic VSMC (HVSMC) with ANG II or PDGF-BB significantly increased binding to human monocytic THP-1 cells and to peripheral blood monocytes. This was inhibited by antibodies to monocyte β 1 - and β 2 -integrins. The binding was also attenuated by blocking VSMC arachidonic acid (AA) metabolism by inhibitors of 12/15-lipoxygenase (12/15-LO) or cyclooxygenase-2 (COX-2). Conversely, binding was enhanced by overexpression of 12/15-LO or COX-2. Direct treatment of HVSMC with AA or its metabolites also increased binding. Furthermore, VSMC derived from 12/15-LO knockout mice displayed reduced binding to mouse monocytic cells relative to genetic control mice. Using specific signal transduction inhibitors, we demonstrated the involvement of Src, phosphoinositide 3-kinase, and MAPKs in ANG II- or PDGF-BB-induced binding. Interestingly, after coculture with HVSMC, THP-1 cell surface expression of the scavenger receptor CD36 was increased. These results show for the first time that growth factors may play additional roles in atherosclerosis by increasing monocyte binding to VSMC via AA metabolism and key signaling pathways. This can lead to monocyte subendothelial retention, CD36 expression, and foam cell formation." @default.
• W2079466437 created "2016-06-24" @default.
• W2079466437 creator A5006564735 @default.
• W2079466437 creator A5044566437 @default.
• W2079466437 creator A5084437282 @default.
• W2079466437 date "2004-09-01" @default.
• W2079466437 modified "2023-10-14" @default.
• W2079466437 title "Growth factors induce monocyte binding to vascular smooth muscle cells: implications for monocyte retention in atherosclerosis" @default.
• W2079466437 cites W1505047300 @default.
• W2079466437 cites W1567124203 @default.
• W2079466437 cites W1751272410 @default.
• W2079466437 cites W1856590789 @default.
• W2079466437 cites W1964619557 @default.
• W2079466437 cites W1969847072 @default.
• W2079466437 cites W1981164988 @default.
• W2079466437 cites W1995145529 @default.
• W2079466437 cites W1997179766 @default.
• W2079466437 cites W1999360913 @default.
• W2079466437 cites W2011988431 @default.
• W2079466437 cites W2027648305 @default.
• W2079466437 cites W2029472372 @default.
• W2079466437 cites W2054233827 @default.
• W2079466437 cites W2055557483 @default.
• W2079466437 cites W2059204108 @default.
• W2079466437 cites W2061587443 @default.
• W2079466437 cites W2066365098 @default.
• W2079466437 cites W2066963386 @default.
• W2079466437 cites W2069408960 @default.
• W2079466437 cites W2078043039 @default.
• W2079466437 cites W2080373577 @default.
• W2079466437 cites W2084120431 @default.
• W2079466437 cites W2089190393 @default.
• W2079466437 cites W2097103756 @default.
• W2079466437 cites W2107953123 @default.
• W2079466437 cites W2112283054 @default.
• W2079466437 cites W2121795847 @default.
• W2079466437 cites W2123066945 @default.
• W2079466437 cites W2133464116 @default.
• W2079466437 cites W2137570167 @default.
• W2079466437 cites W2137948074 @default.
• W2079466437 cites W2149303684 @default.
• W2079466437 cites W2150385839 @default.
• W2079466437 cites W2153245546 @default.
• W2079466437 cites W2155373904 @default.
• W2079466437 cites W2166469889 @default.
• W2079466437 cites W2169037791 @default.
• W2079466437 doi "https://doi.org/10.1152/ajpcell.00170.2004" @default.
• W2079466437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15140748" @default.
• W2079466437 hasPublicationYear "2004" @default.
• W2079466437 type Work @default.
• W2079466437 sameAs 2079466437 @default.
• W2079466437 citedByCount "60" @default.
• W2079466437 countsByYear W20794664372012 @default.
• W2079466437 countsByYear W20794664372013 @default.
• W2079466437 countsByYear W20794664372014 @default.
• W2079466437 countsByYear W20794664372015 @default.
• W2079466437 countsByYear W20794664372016 @default.
• W2079466437 countsByYear W20794664372017 @default.
• W2079466437 countsByYear W20794664372018 @default.
• W2079466437 countsByYear W20794664372019 @default.
• W2079466437 countsByYear W20794664372020 @default.
• W2079466437 countsByYear W20794664372021 @default.
• W2079466437 countsByYear W20794664372023 @default.
• W2079466437 crossrefType "journal-article" @default.
• W2079466437 hasAuthorship W2079466437A5006564735 @default.
• W2079466437 hasAuthorship W2079466437A5044566437 @default.
• W2079466437 hasAuthorship W2079466437A5084437282 @default.
• W2079466437 hasConcept C126322002 @default.
• W2079466437 hasConcept C134018914 @default.
• W2079466437 hasConcept C170493617 @default.
• W2079466437 hasConcept C180361614 @default.
• W2079466437 hasConcept C185592680 @default.
• W2079466437 hasConcept C2775960820 @default.
• W2079466437 hasConcept C2779395532 @default.
• W2079466437 hasConcept C2779828298 @default.
• W2079466437 hasConcept C2781184567 @default.
• W2079466437 hasConcept C2781294074 @default.
• W2079466437 hasConcept C2992686903 @default.
• W2079466437 hasConcept C55493867 @default.
• W2079466437 hasConcept C62478195 @default.
• W2079466437 hasConcept C71924100 @default.
• W2079466437 hasConcept C86803240 @default.
• W2079466437 hasConcept C95444343 @default.
• W2079466437 hasConceptScore W2079466437C126322002 @default.
• W2079466437 hasConceptScore W2079466437C134018914 @default.
• W2079466437 hasConceptScore W2079466437C170493617 @default.
• W2079466437 hasConceptScore W2079466437C180361614 @default.
• W2079466437 hasConceptScore W2079466437C185592680 @default.
• W2079466437 hasConceptScore W2079466437C2775960820 @default.
• W2079466437 hasConceptScore W2079466437C2779395532 @default.
• W2079466437 hasConceptScore W2079466437C2779828298 @default.
• W2079466437 hasConceptScore W2079466437C2781184567 @default.
• W2079466437 hasConceptScore W2079466437C2781294074 @default.
• W2079466437 hasConceptScore W2079466437C2992686903 @default.
• W2079466437 hasConceptScore W2079466437C55493867 @default.
• W2079466437 hasConceptScore W2079466437C62478195 @default.
• W2079466437 hasConceptScore W2079466437C71924100 @default.
• W2079466437 hasConceptScore W2079466437C86803240 @default.

• next