FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079467056> ?p ?o ?g. }

• W2079467056 endingPage "F1012" @default.
• W2079467056 startingPage "F1006" @default.
• W2079467056 abstract "During metanephric kidney development, renin expression in the renal vasculature begins in larger vessels, shifting to smaller vessels and finally remaining restricted to the terminal portions of afferent arterioles at the entrance into the glomerular capillary network. The mechanisms determining the successive expression of renin along the vascular axis of the kidney are not well understood. Since the cAMP signaling cascade plays a central role in the regulation of both renin secretion and synthesis in the adult kidney, it seemed feasible that this pathway might also be critical for renin expression during kidney development. In the present study we determined the spatiotemporal development of renin expression and the development of the preglomerular arterial tree in mouse kidneys with renin cell-specific deletion of G(s)alpha, a core element for receptor activation of adenylyl cyclases. We found that in the absence of the G(s)alpha protein, renin expression was largely absent in the kidneys at any developmental stage, accompanied by alterations in the development of the preglomerular arterial tree. These data indicate that the maintenance of renin expression following a specific spatiotemporal pattern along the preglomerular vasculature critically depends on the availability of G(s)alpha. We infer from our data that the cAMP signaling pathway is not only critical for the regulation of renin synthesis and secretion in the mature kidney but that it also is critical for establishing the juxtaglomerular expression site of renin during development." @default.
• W2079467056 created "2016-06-24" @default.
• W2079467056 creator A5000340172 @default.
• W2079467056 creator A5003919068 @default.
• W2079467056 creator A5012718640 @default.
• W2079467056 creator A5028634538 @default.
• W2079467056 creator A5029074504 @default.
• W2079467056 creator A5047588453 @default.
• W2079467056 creator A5059178679 @default.
• W2079467056 creator A5067640397 @default.
• W2079467056 creator A5070999479 @default.
• W2079467056 creator A5086331770 @default.
• W2079467056 creator A5088985377 @default.
• W2079467056 date "2009-05-01" @default.
• W2079467056 modified "2023-10-18" @default.
• W2079467056 title "Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway" @default.
• W2079467056 cites W1505231237 @default.
• W2079467056 cites W1546796591 @default.
• W2079467056 cites W1762073497 @default.
• W2079467056 cites W1851629571 @default.
• W2079467056 cites W1965075408 @default.
• W2079467056 cites W1973600469 @default.
• W2079467056 cites W1981007500 @default.
• W2079467056 cites W1995746843 @default.
• W2079467056 cites W2000496244 @default.
• W2079467056 cites W2003122043 @default.
• W2079467056 cites W2003306808 @default.
• W2079467056 cites W2013206507 @default.
• W2079467056 cites W2013721854 @default.
• W2079467056 cites W2019678866 @default.
• W2079467056 cites W2025162115 @default.
• W2079467056 cites W2040181550 @default.
• W2079467056 cites W2042950885 @default.
• W2079467056 cites W2047138625 @default.
• W2079467056 cites W2049888726 @default.
• W2079467056 cites W2050660386 @default.
• W2079467056 cites W2051834155 @default.
• W2079467056 cites W2054393508 @default.
• W2079467056 cites W2058024551 @default.
• W2079467056 cites W2059789008 @default.
• W2079467056 cites W2081952415 @default.
• W2079467056 cites W2096629784 @default.
• W2079467056 cites W2097132210 @default.
• W2079467056 cites W2109616826 @default.
• W2079467056 cites W2111455859 @default.
• W2079467056 cites W2116332549 @default.
• W2079467056 cites W2123295634 @default.
• W2079467056 cites W2126690315 @default.
• W2079467056 cites W2145445649 @default.
• W2079467056 cites W2151411997 @default.
• W2079467056 cites W2153201315 @default.
• W2079467056 cites W2163634050 @default.
• W2079467056 cites W2183325145 @default.
• W2079467056 cites W2186088125 @default.
• W2079467056 cites W2323753532 @default.
• W2079467056 cites W2325271872 @default.
• W2079467056 cites W2402218235 @default.
• W2079467056 cites W2412606606 @default.
• W2079467056 cites W2419103365 @default.
• W2079467056 cites W2119699031 @default.
• W2079467056 doi "https://doi.org/10.1152/ajprenal.90448.2008" @default.
• W2079467056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4067120" @default.
• W2079467056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19261741" @default.
• W2079467056 hasPublicationYear "2009" @default.
• W2079467056 type Work @default.
• W2079467056 sameAs 2079467056 @default.
• W2079467056 citedByCount "43" @default.
• W2079467056 countsByYear W20794670562012 @default.
• W2079467056 countsByYear W20794670562013 @default.
• W2079467056 countsByYear W20794670562014 @default.
• W2079467056 countsByYear W20794670562015 @default.
• W2079467056 countsByYear W20794670562017 @default.
• W2079467056 countsByYear W20794670562018 @default.
• W2079467056 countsByYear W20794670562019 @default.
• W2079467056 countsByYear W20794670562020 @default.
• W2079467056 countsByYear W20794670562021 @default.
• W2079467056 countsByYear W20794670562022 @default.
• W2079467056 countsByYear W20794670562023 @default.
• W2079467056 crossrefType "journal-article" @default.
• W2079467056 hasAuthorship W2079467056A5000340172 @default.
• W2079467056 hasAuthorship W2079467056A5003919068 @default.
• W2079467056 hasAuthorship W2079467056A5012718640 @default.
• W2079467056 hasAuthorship W2079467056A5028634538 @default.
• W2079467056 hasAuthorship W2079467056A5029074504 @default.
• W2079467056 hasAuthorship W2079467056A5047588453 @default.
• W2079467056 hasAuthorship W2079467056A5059178679 @default.
• W2079467056 hasAuthorship W2079467056A5067640397 @default.
• W2079467056 hasAuthorship W2079467056A5070999479 @default.
• W2079467056 hasAuthorship W2079467056A5086331770 @default.
• W2079467056 hasAuthorship W2079467056A5088985377 @default.
• W2079467056 hasBestOaLocation W20794670562 @default.
• W2079467056 hasConcept C104317684 @default.
• W2079467056 hasConcept C126322002 @default.
• W2079467056 hasConcept C134018914 @default.
• W2079467056 hasConcept C145103041 @default.
• W2079467056 hasConcept C170493617 @default.
• W2079467056 hasConcept C198710026 @default.
• W2079467056 hasConcept C2777632694 @default.

• next