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• W2079468061 abstract "Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity. The solubility enhancements come from strategic placement of a morpholinylalkoxy substituent in the entrance channel of the NNRTI binding site. Compound 4d shows low-nanomolar activity similar to etravirine towards wild-type HIV-1 and key viral variants." @default.
• W2079468061 created "2016-06-24" @default.
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• W2079468061 date "2013-09-01" @default.
• W2079468061 modified "2023-10-17" @default.
• W2079468061 title "Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility" @default.
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• W2079468061 doi "https://doi.org/10.1016/j.bmcl.2013.06.091" @default.
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