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• W2079472092 startingPage "95" @default.
• W2079472092 abstract "Recent evidence suggests a predominant role for potassium (K) efflux in apoptotic cell death yet there exists controversy as to the exact nature of this involvement of K. In the present study we tested the anti-apoptotic efficacy of K channel blockers, tetraethylammonium Cl (TEA), and high extracellular K, the sodium (Na) channel blocker, tetrodotoxin (TTX) and the Cl channel blocker, 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid, (SITS) against staurosporine-induced apoptosis in primary rat cortical cultures. Surprisingly, we failed to observe anti-apoptotic effects with TEA, high K or TTX. We did, however, observe significant dose-dependent inhibition of apoptosis with SITS. In conclusion we demonstrate no role for K or Na in neuronal apoptosis, but rather an important role for a SITS-sensitive mechanism such as Cl." @default.
• W2079472092 created "2016-06-24" @default.
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• W2079472092 date "2002-12-01" @default.
• W2079472092 modified "2023-10-14" @default.
• W2079472092 title "Role for chloride but not potassium channels in apoptosis in primary rat cortical cultures" @default.
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• W2079472092 doi "https://doi.org/10.1016/s0304-3940(02)01107-2" @default.
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