Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079473225> ?p ?o ?g. }
- W2079473225 endingPage "1759" @default.
- W2079473225 startingPage "1740" @default.
- W2079473225 abstract "Connective tissue growth factor (CTGF) is a cysteine-rich protein the synthesis and secretion of which are hypothesized to be selectively regulated by activins and other members of the TGF-β superfamily. To investigate the in vivo roles of CTGF in female reproduction, we generated Ctgf ovarian and uterine conditional knockout (cKO) mice. Ctgf cKO mice exhibit severe subfertility and multiple reproductive defects including disrupted follicle development, decreased ovulation rates, increased numbers of corpus luteum, and smaller but functionally normal uterine horns. Steroidogenesis is disrupted in the Ctgf cKO mice, leading to increased levels of serum progesterone. We show that disrupted follicle development is accompanied by a significant increase in granulosa cell apoptosis. Moreover, despite normal cumulus expansion, Ctgf cKO mice exhibit a significant decrease in oocytes ovulated, likely due to impaired ovulatory process. During analyses of mRNA expression, we discovered that Ctgf cKO granulosa cells show gene expression changes similar to our previously reported granulosa cell-specific knockouts of activin and Smad4, the common TGF-β family intracellular signaling protein. We also discovered a significant down-regulation of Adamts1, a progesterone-regulated gene that is critical for the remodeling of extracellular matrix surrounding granulosa cells of preovulatory follicles. These findings demonstrate that CTGF is a downstream mediator in TGF-β and progesterone signaling cascades and is necessary for normal follicle development and ovulation." @default.
- W2079473225 created "2016-06-24" @default.
- W2079473225 creator A5014717847 @default.
- W2079473225 creator A5015194203 @default.
- W2079473225 creator A5016994035 @default.
- W2079473225 creator A5039610814 @default.
- W2079473225 creator A5050632280 @default.
- W2079473225 creator A5064070422 @default.
- W2079473225 creator A5069048623 @default.
- W2079473225 date "2011-10-01" @default.
- W2079473225 modified "2023-10-06" @default.
- W2079473225 title "Connective Tissue Growth Factor Is Required for Normal Follicle Development and Ovulation" @default.
- W2079473225 cites W1481014355 @default.
- W2079473225 cites W1558210941 @default.
- W2079473225 cites W1600346513 @default.
- W2079473225 cites W1793987231 @default.
- W2079473225 cites W1835352600 @default.
- W2079473225 cites W1942474822 @default.
- W2079473225 cites W1963482245 @default.
- W2079473225 cites W1964941505 @default.
- W2079473225 cites W1966188866 @default.
- W2079473225 cites W1967949556 @default.
- W2079473225 cites W1968193801 @default.
- W2079473225 cites W1968409042 @default.
- W2079473225 cites W1971486701 @default.
- W2079473225 cites W1971829574 @default.
- W2079473225 cites W1972810033 @default.
- W2079473225 cites W1974307668 @default.
- W2079473225 cites W1974690510 @default.
- W2079473225 cites W1975899660 @default.
- W2079473225 cites W1977459280 @default.
- W2079473225 cites W1978380407 @default.
- W2079473225 cites W1979093446 @default.
- W2079473225 cites W1979899399 @default.
- W2079473225 cites W1982713782 @default.
- W2079473225 cites W1987331190 @default.
- W2079473225 cites W1989357942 @default.
- W2079473225 cites W1991886593 @default.
- W2079473225 cites W1994515954 @default.
- W2079473225 cites W1995418376 @default.
- W2079473225 cites W1997365784 @default.
- W2079473225 cites W1999469108 @default.
- W2079473225 cites W1999512677 @default.
- W2079473225 cites W2009407308 @default.
- W2079473225 cites W2009816486 @default.
- W2079473225 cites W2011750263 @default.
- W2079473225 cites W2014630371 @default.
- W2079473225 cites W2023054545 @default.
- W2079473225 cites W2023967584 @default.
- W2079473225 cites W2027232305 @default.
- W2079473225 cites W2033316270 @default.
- W2079473225 cites W2034277114 @default.
- W2079473225 cites W2035000884 @default.
- W2079473225 cites W2037323918 @default.
- W2079473225 cites W2040919102 @default.
- W2079473225 cites W2042249648 @default.
- W2079473225 cites W2042589651 @default.
- W2079473225 cites W2047083811 @default.
- W2079473225 cites W2064345811 @default.
- W2079473225 cites W2064757398 @default.
- W2079473225 cites W2066664707 @default.
- W2079473225 cites W2071768807 @default.
- W2079473225 cites W2073141218 @default.
- W2079473225 cites W2074426211 @default.
- W2079473225 cites W2082559087 @default.
- W2079473225 cites W2084241850 @default.
- W2079473225 cites W2086870841 @default.
- W2079473225 cites W2088613090 @default.
- W2079473225 cites W2090619182 @default.
- W2079473225 cites W2092224562 @default.
- W2079473225 cites W2093514133 @default.
- W2079473225 cites W2095125236 @default.
- W2079473225 cites W2099569610 @default.
- W2079473225 cites W2100646314 @default.
- W2079473225 cites W2102138077 @default.
- W2079473225 cites W2104001105 @default.
- W2079473225 cites W2104762951 @default.
- W2079473225 cites W2106232223 @default.
- W2079473225 cites W2107277218 @default.
- W2079473225 cites W2107932801 @default.
- W2079473225 cites W2109055118 @default.
- W2079473225 cites W2112417973 @default.
- W2079473225 cites W2112646111 @default.
- W2079473225 cites W2112760662 @default.
- W2079473225 cites W2114854250 @default.
- W2079473225 cites W2117100312 @default.
- W2079473225 cites W2118506472 @default.
- W2079473225 cites W2119104675 @default.
- W2079473225 cites W2120842955 @default.
- W2079473225 cites W2126391360 @default.
- W2079473225 cites W2126516708 @default.
- W2079473225 cites W2129300074 @default.
- W2079473225 cites W2132943628 @default.
- W2079473225 cites W2134799150 @default.
- W2079473225 cites W2137702233 @default.
- W2079473225 cites W2142646818 @default.
- W2079473225 cites W2142799375 @default.
- W2079473225 cites W2146913091 @default.