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• W2079473465 endingPage "1033" @default.
• W2079473465 startingPage "1023" @default.
• W2079473465 abstract "Abstract The ability of a cell to sense and respond to DNA damage is essential for genome stability. An important aspect of the response is arrest of the cell cycle, presumably to allow time for repair. Ataxia telangiectasia mutated (ATM) and ATR are essential for such cell-cycle control, but some observations suggest that they also play a direct role in DNA repair. The Drosophila ortholog of ATR, MEI-41, mediates the DNA damage-dependent G2-M checkpoint. We examined the role of MEI-41 in repair of double-strand breaks (DSBs) induced by P-element excision. We found that mei-41 mutants are defective in completing the later steps of homologous recombination repair, but have no defects in end-joining repair. We hypothesized that these repair defects are the result of loss of checkpoint control. To test this, we genetically reduced mitotic cyclin levels and also examined repair in grp (DmChk1) and lok (DmChk2) mutants. Our results suggest that a significant component of the repair defects is due to loss of MEI-41-dependent cell cycle regulation. However, this does not account for all of the defects we observed. We propose a novel role for MEI-41 in DSB repair, independent of the Chk1/Chk2-mediated checkpoint response." @default.
• W2079473465 created "2016-06-24" @default.
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• W2079473465 creator A5064269861 @default.
• W2079473465 date "2007-03-01" @default.
• W2079473465 modified "2023-10-01" @default.
• W2079473465 title "Drosophila ATR in Double-Strand Break Repair" @default.
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• W2079473465 cites W1888032283 @default.
• W2079473465 cites W1895360660 @default.
• W2079473465 cites W1964609719 @default.
• W2079473465 cites W1972173160 @default.
• W2079473465 cites W1979568780 @default.
• W2079473465 cites W1980641289 @default.
• W2079473465 cites W1985544638 @default.
• W2079473465 cites W1986011493 @default.
• W2079473465 cites W1989136612 @default.
• W2079473465 cites W1989557466 @default.
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• W2079473465 cites W2001854404 @default.
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• W2079473465 cites W2028307977 @default.
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• W2079473465 cites W2035154953 @default.
• W2079473465 cites W2040988046 @default.
• W2079473465 cites W2043812345 @default.
• W2079473465 cites W2044963929 @default.
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• W2079473465 cites W2102752109 @default.
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• W2079473465 cites W2146176862 @default.
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• W2079473465 doi "https://doi.org/10.1534/genetics.106.067330" @default.
• W2079473465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1840096" @default.
• W2079473465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17194776" @default.
• W2079473465 hasPublicationYear "2007" @default.
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