FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079474257> ?p ?o ?g. }

• W2079474257 endingPage "7599" @default.
• W2079474257 startingPage "7594" @default.
• W2079474257 abstract "Treatment of many neuronal degenerative disorders will require delivery of a therapeutic protein to neurons or glial cells across the whole CNS. The presence of the blood-brain barrier hampers the delivery of these proteins from the blood, thus necessitating a new method for delivery. Receptors on the blood-brain barrier bind ligands to facilitate their transport to the CNS; therefore, we hypothesized that by targeting these receptors, we may be able to deliver proteins to the CNS for therapy. Here, we report the use of the lentivirus vector system to deliver the lysosomal enzyme glucocerebrosidase and a secreted form of GFP to the neurons and astrocytes in the CNS. We fused the low-density lipoprotein receptor-binding domain of the apolipoprotein B to the targeted protein. This approach proved to be feasible for delivery of the protein and could possibly be used as a general method for delivery of therapeutic proteins to the CNS." @default.
• W2079474257 created "2016-06-24" @default.
• W2079474257 creator A5014409494 @default.
• W2079474257 creator A5088266291 @default.
• W2079474257 date "2007-05-01" @default.
• W2079474257 modified "2023-10-11" @default.
• W2079474257 title "Targeted delivery of proteins across the blood–brain barrier" @default.
• W2079474257 cites W1497282978 @default.
• W2079474257 cites W1576642143 @default.
• W2079474257 cites W1963021413 @default.
• W2079474257 cites W1967908989 @default.
• W2079474257 cites W1970788491 @default.
• W2079474257 cites W1979823761 @default.
• W2079474257 cites W1981449360 @default.
• W2079474257 cites W1981802108 @default.
• W2079474257 cites W2000913322 @default.
• W2079474257 cites W2019893496 @default.
• W2079474257 cites W2024168872 @default.
• W2079474257 cites W2041229020 @default.
• W2079474257 cites W2069050425 @default.
• W2079474257 cites W2081844190 @default.
• W2079474257 cites W2081922902 @default.
• W2079474257 cites W2082844918 @default.
• W2079474257 cites W2084744450 @default.
• W2079474257 cites W2095512576 @default.
• W2079474257 cites W2104141601 @default.
• W2079474257 cites W2118309500 @default.
• W2079474257 cites W2141775501 @default.
• W2079474257 cites W2158496649 @default.
• W2079474257 cites W2166368787 @default.
• W2079474257 cites W250576690 @default.
• W2079474257 cites W2581259096 @default.
• W2079474257 cites W4247546166 @default.
• W2079474257 doi "https://doi.org/10.1073/pnas.0702170104" @default.
• W2079474257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1857226" @default.
• W2079474257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17463083" @default.
• W2079474257 hasPublicationYear "2007" @default.
• W2079474257 type Work @default.
• W2079474257 sameAs 2079474257 @default.
• W2079474257 citedByCount "200" @default.
• W2079474257 countsByYear W20794742572012 @default.
• W2079474257 countsByYear W20794742572013 @default.
• W2079474257 countsByYear W20794742572014 @default.
• W2079474257 countsByYear W20794742572015 @default.
• W2079474257 countsByYear W20794742572016 @default.
• W2079474257 countsByYear W20794742572017 @default.
• W2079474257 countsByYear W20794742572018 @default.
• W2079474257 countsByYear W20794742572019 @default.
• W2079474257 countsByYear W20794742572020 @default.
• W2079474257 countsByYear W20794742572021 @default.
• W2079474257 countsByYear W20794742572022 @default.
• W2079474257 countsByYear W20794742572023 @default.
• W2079474257 crossrefType "journal-article" @default.
• W2079474257 hasAuthorship W2079474257A5014409494 @default.
• W2079474257 hasAuthorship W2079474257A5088266291 @default.
• W2079474257 hasBestOaLocation W20794742571 @default.
• W2079474257 hasConcept C104317684 @default.
• W2079474257 hasConcept C111599444 @default.
• W2079474257 hasConcept C135983454 @default.
• W2079474257 hasConcept C142724271 @default.
• W2079474257 hasConcept C169760540 @default.
• W2079474257 hasConcept C170493617 @default.
• W2079474257 hasConcept C2778163477 @default.
• W2079474257 hasConcept C2778402981 @default.
• W2079474257 hasConcept C2779134260 @default.
• W2079474257 hasConcept C2780072125 @default.
• W2079474257 hasConcept C43554185 @default.
• W2079474257 hasConcept C529278444 @default.
• W2079474257 hasConcept C55493867 @default.
• W2079474257 hasConcept C57089818 @default.
• W2079474257 hasConcept C71924100 @default.
• W2079474257 hasConcept C86803240 @default.
• W2079474257 hasConcept C95444343 @default.
• W2079474257 hasConceptScore W2079474257C104317684 @default.
• W2079474257 hasConceptScore W2079474257C111599444 @default.
• W2079474257 hasConceptScore W2079474257C135983454 @default.
• W2079474257 hasConceptScore W2079474257C142724271 @default.
• W2079474257 hasConceptScore W2079474257C169760540 @default.
• W2079474257 hasConceptScore W2079474257C170493617 @default.
• W2079474257 hasConceptScore W2079474257C2778163477 @default.
• W2079474257 hasConceptScore W2079474257C2778402981 @default.
• W2079474257 hasConceptScore W2079474257C2779134260 @default.
• W2079474257 hasConceptScore W2079474257C2780072125 @default.
• W2079474257 hasConceptScore W2079474257C43554185 @default.
• W2079474257 hasConceptScore W2079474257C529278444 @default.
• W2079474257 hasConceptScore W2079474257C55493867 @default.
• W2079474257 hasConceptScore W2079474257C57089818 @default.
• W2079474257 hasConceptScore W2079474257C71924100 @default.
• W2079474257 hasConceptScore W2079474257C86803240 @default.
• W2079474257 hasConceptScore W2079474257C95444343 @default.
• W2079474257 hasIssue "18" @default.
• W2079474257 hasLocation W20794742571 @default.
• W2079474257 hasLocation W20794742572 @default.
• W2079474257 hasLocation W20794742573 @default.
• W2079474257 hasLocation W20794742574 @default.
• W2079474257 hasOpenAccess W2079474257 @default.
• W2079474257 hasPrimaryLocation W20794742571 @default.
• W2079474257 hasRelatedWork W1587611090 @default.

• next