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- W2079475729 abstract "The effects of two intraperitoneal injections of 17β-estradiol (E 2 ) over 7 days were studied on thyroid hormone plasma levels and on activities of thyroxine (T 4 ), 3,5,3'-triiodothyronine (T 3 ), and 3,3',5'-triiodothyronine (rT 3 ) outer-ring deiodination (ORD) and inner-ring deiodination (IRD) pathways in various tissues of female and male rainbow trout (Oncorhynchus mykiss (Walbaum, 1792)). E 2 administered to adult females and males at different stages of sexual maturity increased liver mass, depressed plasma T 3 levels with no change in plasma T 4 levels, and severely decreased liver T 4 ORD activity. E 2 also modestly depressed hepatic rT 3 ORD activity, but only at low substrate levels, and had no consistent effect on the hepatic IRD pathways. There were no E 2 -induced changes in brain, gill, or heart deiodination, but E 2 increased kidney T 3 IRD activity. In contrast, an all-female stock of trout with rudimentary ovaries responded to E 2 with an increase in liver mass but without change in plasma T 4 and T 3 levels or liver and brain deiodination activities. In conclusion, the decrease in plasma T 3 levels in both male and female adult E 2 -injected trout may be due to both decreased hepatic T 3 production and increased renal T 3 degradation. However, thyroidal responses to E 2 depend on physiological/developmental state and were absent in a highly immature all-female trout stock." @default.
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- W2079475729 date "2005-04-01" @default.
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- W2079475729 title "The effects of 17β-estradiol injections on thyroid hormone deiodination pathways in liver and other tissues of female and male rainbow trout (Oncorhynchus mykiss) at different stages of sexual maturity" @default.
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