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- W2079479009 abstract "We have examined the role of the GABAergic system in the opioid inhibition of endogenous acetylcholine (ACh) release from rat neostriatal slices by blocking either gamma-aminobutyric acid-A (GABAA) or GABAB receptors. GABAergic antagonists (bicuculline or phaclofen) completely blocked mu- (morphine or DAGO) and delta-opioid (DPDPE) inhibition of glutamate-evoked endogenous ACh release in a concentration-dependent manner. However, GABA antagonists were ineffective in blocking the opioid inhibition of potassium-evoked endogenous ACh release. These findings point to the important role of the GABAergic system in the regulation of mu- and delta-opioid inhibition of cholinergic neurons stimulated by glutamate." @default.
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- W2079479009 date "1990-12-01" @default.
- W2079479009 modified "2023-09-23" @default.
- W2079479009 title "GABAA and GABAB antagonists prevent the opioid inhibition of endogenous acetylcholine release evoked by glutamate from rat neostriatal slices" @default.
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- W2079479009 doi "https://doi.org/10.1016/0304-3940(90)90038-b" @default.
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