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• W2079479950 abstract "Nanoparticles consisting of human therapeutic drugs are suggested as a promising strategy for targeted and localized drug delivery to tumor cells. In this study, 5-fluorouracil (5-FU) encapsulated chitosan nanoparticles were prepared in order to investigate potentials of localized drug delivery for tumor environment due to pH sensitivity of chitosan nanoparticles. Optimization of chitosan and 5-FU encapsulated nanoparticles production revealed<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mn>148.8</mml:mn><mml:mo>±</mml:mo><mml:mn>1.1</mml:mn></mml:math> nm and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mn>243.1</mml:mn><mml:mo>±</mml:mo><mml:mn>17.9</mml:mn></mml:math> nm particle size diameters with narrow size distributions, which are confirmed by scanning electron microscope (SEM) images. The challenge was to investigate drug delivery of 5-FU encapsulated chitosan nanoparticles due to varied pH changes. To achieve this objective, pH sensitivity of prepared chitosan nanoparticle was evaluated and results showed a significant swelling response for pH 5 with particle diameter of ∼450 nm. In vitro release studies indicated a controlled and sustained release of 5-FU from chitosan nanoparticles with the release amounts of 29.1–60.8% due to varied pH environments after 408 h of the incubation period. pH sensitivity is confirmed by mathematical modeling of release kinetics since chitosan nanoparticles showed stimuli-induced release. Results suggested that 5-FU encapsulated chitosan nanoparticles can be launched as pH-responsive smart drug delivery agents for possible applications of cancer treatments." @default.
• W2079479950 created "2016-06-24" @default.
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• W2079479950 date "2012-01-01" @default.
• W2079479950 modified "2023-10-14" @default.
• W2079479950 title "5-Fluorouracil Encapsulated Chitosan Nanoparticles for pH-Stimulated Drug Delivery: Evaluation of Controlled Release Kinetics" @default.
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• W2079479950 doi "https://doi.org/10.1155/2012/313961" @default.
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