FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079480188> ?p ?o ?g. }

• W2079480188 endingPage "78" @default.
• W2079480188 startingPage "73" @default.
• W2079480188 abstract "To investigate the protective effect of glucagon–like peptid–1 (GLP–1) against cardiac microvascular endothelial cell (CMECs) injured by high glucose. CMECs were isolated and cultured. Superoxide assay kit and dihydroethidine (DHE) staining were used to assess oxidative stress. TUNEL staining and caspase 3 expression were used to assess the apoptosis of CMECs. H89 was used to inhibit cAMP/PKA pathway; fasudil was used to inhibit Rho/ROCK pathway. The protein expressions of Rho, ROCK were examined by Western blot analysis. High glucose increased the production of ROS, the activity of NADPH, the apoptosis rate and the expression level of Rho/ROCK in CMECs, while GLP–1 decreased high glucose–induced ROS production, the NADPH activity and the apoptosis rate and the expression level of Rho/ROCK in CMECs, the difference were statistically significant (P<0.05). GLP–1 could protect the cardiac microvessels against oxidative stress and apoptosis. The protective effects of GLP–1 are dependent on downstream inhibition of Rho through a cAMP/PKA–dependent manner, resulting in a subsequent decrease in the expression of NADPH oxidase." @default.
• W2079480188 created "2016-06-24" @default.
• W2079480188 creator A5024100735 @default.
• W2079480188 creator A5034727850 @default.
• W2079480188 creator A5039107335 @default.
• W2079480188 creator A5048922666 @default.
• W2079480188 creator A5065037766 @default.
• W2079480188 creator A5065957278 @default.
• W2079480188 creator A5087962721 @default.
• W2079480188 creator A5089737440 @default.
• W2079480188 date "2015-01-01" @default.
• W2079480188 modified "2023-09-26" @default.
• W2079480188 title "Glucagon–like peptide–1 protects against cardiac microvascular endothelial cells injured by high glucose" @default.
• W2079480188 cites W1526784932 @default.
• W2079480188 cites W1605841001 @default.
• W2079480188 cites W1974255231 @default.
• W2079480188 cites W1975591028 @default.
• W2079480188 cites W1983883248 @default.
• W2079480188 cites W2025566748 @default.
• W2079480188 cites W2033634023 @default.
• W2079480188 cites W2055054551 @default.
• W2079480188 cites W2060571859 @default.
• W2079480188 cites W2078096259 @default.
• W2079480188 cites W2085821308 @default.
• W2079480188 cites W2090360729 @default.
• W2079480188 cites W2092434810 @default.
• W2079480188 cites W2105731956 @default.
• W2079480188 cites W2108122035 @default.
• W2079480188 cites W2117213923 @default.
• W2079480188 cites W2119695795 @default.
• W2079480188 cites W2121103105 @default.
• W2079480188 cites W2121633948 @default.
• W2079480188 cites W2130471781 @default.
• W2079480188 cites W2137616809 @default.
• W2079480188 cites W2142400535 @default.
• W2079480188 cites W2143036678 @default.
• W2079480188 cites W2152931480 @default.
• W2079480188 cites W2160495818 @default.
• W2079480188 cites W2162406201 @default.
• W2079480188 cites W4242364069 @default.
• W2079480188 cites W47631135 @default.
• W2079480188 doi "https://doi.org/10.1016/s1995-7645(14)60191-7" @default.
• W2079480188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25901929" @default.
• W2079480188 hasPublicationYear "2015" @default.
• W2079480188 type Work @default.
• W2079480188 sameAs 2079480188 @default.
• W2079480188 citedByCount "7" @default.
• W2079480188 countsByYear W20794801882015 @default.
• W2079480188 countsByYear W20794801882016 @default.
• W2079480188 countsByYear W20794801882017 @default.
• W2079480188 countsByYear W20794801882019 @default.
• W2079480188 countsByYear W20794801882021 @default.
• W2079480188 crossrefType "journal-article" @default.
• W2079480188 hasAuthorship W2079480188A5024100735 @default.
• W2079480188 hasAuthorship W2079480188A5034727850 @default.
• W2079480188 hasAuthorship W2079480188A5039107335 @default.
• W2079480188 hasAuthorship W2079480188A5048922666 @default.
• W2079480188 hasAuthorship W2079480188A5065037766 @default.
• W2079480188 hasAuthorship W2079480188A5065957278 @default.
• W2079480188 hasAuthorship W2079480188A5087962721 @default.
• W2079480188 hasAuthorship W2079480188A5089737440 @default.
• W2079480188 hasBestOaLocation W20794801881 @default.
• W2079480188 hasConcept C104317684 @default.
• W2079480188 hasConcept C134018914 @default.
• W2079480188 hasConcept C185592680 @default.
• W2079480188 hasConcept C190283241 @default.
• W2079480188 hasConcept C196795494 @default.
• W2079480188 hasConcept C2776151105 @default.
• W2079480188 hasConcept C2776398474 @default.
• W2079480188 hasConcept C2776415932 @default.
• W2079480188 hasConcept C2777180221 @default.
• W2079480188 hasConcept C2778563252 @default.
• W2079480188 hasConcept C2779719074 @default.
• W2079480188 hasConcept C48349386 @default.
• W2079480188 hasConcept C55493867 @default.
• W2079480188 hasConcept C555293320 @default.
• W2079480188 hasConcept C71315377 @default.
• W2079480188 hasConcept C86803240 @default.
• W2079480188 hasConcept C95444343 @default.
• W2079480188 hasConceptScore W2079480188C104317684 @default.
• W2079480188 hasConceptScore W2079480188C134018914 @default.
• W2079480188 hasConceptScore W2079480188C185592680 @default.
• W2079480188 hasConceptScore W2079480188C190283241 @default.
• W2079480188 hasConceptScore W2079480188C196795494 @default.
• W2079480188 hasConceptScore W2079480188C2776151105 @default.
• W2079480188 hasConceptScore W2079480188C2776398474 @default.
• W2079480188 hasConceptScore W2079480188C2776415932 @default.
• W2079480188 hasConceptScore W2079480188C2777180221 @default.
• W2079480188 hasConceptScore W2079480188C2778563252 @default.
• W2079480188 hasConceptScore W2079480188C2779719074 @default.
• W2079480188 hasConceptScore W2079480188C48349386 @default.
• W2079480188 hasConceptScore W2079480188C55493867 @default.
• W2079480188 hasConceptScore W2079480188C555293320 @default.
• W2079480188 hasConceptScore W2079480188C71315377 @default.
• W2079480188 hasConceptScore W2079480188C86803240 @default.
• W2079480188 hasConceptScore W2079480188C95444343 @default.
• W2079480188 hasIssue "1" @default.
• W2079480188 hasLocation W20794801881 @default.

• next