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- W207948150 abstract "ABSTRACT The isolated eye of Aplysia expresses a circadian rhythm of neuronal activity when maintained in culture medium in darkness. The eye contains ~ 5000 neurons of 3 basic types; 2 photoreceptors and 1 secondary neuron. These cells have been studied with intracellular recording and Lucifer yellow dye injection. One receptor type, R, gives graded depolarization to light but is silent during spontaneous dark activity and expression of the circadian rhythm. Another receptor type, H, responds to light with complex depolarization and spiking followed by hyperpolarization and silence. These two receptors may correspond to the microvillus and ciliated photoreceptor seen in electron microscopy studies. Dye injection of each of the receptors shows they have axons in the optic nerve and dendritic branching in the neuropile. The secondary or “D” cells also have axons in the optic nerve and their somata are situated in a non-receptor layer. These cells are autoactive in the dark and are the output neurons of the circadian rhythm of activity. Studies on the cellular mechanisms of the circadian clock show that the daily synthesis of protein is part of the clock mechanism. Protein synthesis inhibitors cause dose dependent lengthening of the period of the clock, and phase dependent phase shifts of the rhythm are obtained when the inhibitors are pulsed. Hypothetically, the circadian clock could consist of protein synthesis on a daily basis, where the protein influences membrane pacemaker and burst activity and also has a negative feedback effect on synthesis at the translational or transcriptional level." @default.
- W207948150 created "2016-06-24" @default.
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- W207948150 date "1981-01-01" @default.
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- W207948150 title "CELLULAR MECHANISMS AND NEURONAL NETWORK OF A CIRCADIAN CLOCK IN THE EYE OF APLYSIA" @default.
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- W207948150 doi "https://doi.org/10.1016/b978-0-08-027344-0.50006-5" @default.
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