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- W2079481608 endingPage "119" @default.
- W2079481608 startingPage "110" @default.
- W2079481608 abstract "Locally advanced rectal cancer (RC) treatment is a challenge, because RC has a high rate of local recurrence. To date preoperative chemoradiotherapy (pCRT) is widely accepted as standard protocol of care for middle-low RC, but complete tumour response rate ranges from 4 to 44% and 5-year local recurrence rate is 6%. Better understanding of molecular biology and carcinogenesis pathways could be used both for pre-neoplastic lesions and locally recurrence diagnosis, and for tumour response prediction to therapy. Circulating molecules, gene expression and protein signature are promising sources to biomarker discovery. Several studies have evaluated potential predictors of response and recently, cell-free Nucleic Acid levels have been associated to tumour response to neoadjuvant therapies. Alternative method is the serum or plasma proteome and peptidome analysis. It may be ideally suited for its minimal invasiveness and it can be repeated at multiple time points throughout the treatment in contrast to tissue-based methods which still remain the most reliable and specific approach. Many studies have analyzed preoperative rectal tissue prognostic factor, but data are controversial or not confirmed." @default.
- W2079481608 created "2016-06-24" @default.
- W2079481608 creator A5000142787 @default.
- W2079481608 creator A5008850465 @default.
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- W2079481608 creator A5053030044 @default.
- W2079481608 creator A5055252814 @default.
- W2079481608 creator A5067570459 @default.
- W2079481608 date "2014-01-01" @default.
- W2079481608 modified "2023-10-17" @default.
- W2079481608 title "Predictive response biomarkers in rectal cancer neoadjuvant treatment" @default.
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- W2079481608 doi "https://doi.org/10.2741/s418" @default.
- W2079481608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24389265" @default.
- W2079481608 hasPublicationYear "2014" @default.