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• W2079482822 abstract "The possible influence of apolipoprotein E (ApoE) genotype on the response to acetylcholinesterase inhibitor therapy in patients with Alzheimer's disease (AD) remains a matter of controversy. In order to address this issue, we investigated the effects of ApoE genotype on the clinical response to donepezil in patients with mild to moderate AD.An open study was carried out in 51 patients with probable AD who were treated with 5-10 mg of donepezil per day for 48 weeks.Eighteen (35.3%) of the 51 patients had 1 or 2 ApoE epsilon4 alleles. ApoE epsilon4 carriers with AD showed a mean 1.1-point increase from the baseline score of 23.9 on the 70-point Alzheimer's Disease Assessment Scale-Cognitive Component at 48 weeks, while the ApoE epsilon4 noncarrier group showed a 3.1-point increase from the baseline score of 22.5 (p = 0.03). The ApoE epsilon4 carrier group exhibited a mean 0.13-point worsening from the baseline score of 0.97 on the Korean Instrumental Activities of Daily Living at 48 weeks, while the ApoE epsilon4 noncarrier group exhibited a 0.17-point worsening from the baseline score of 0.64 (p = 0.05).AD patients who carry the ApoE epsilon4 allele may respond more favorably to donepezil than epsilon4 noncarriers." @default.
• W2079482822 created "2016-06-24" @default.
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• W2079482822 date "2008-01-01" @default.
• W2079482822 modified "2023-10-01" @default.
• W2079482822 title "Effect of <i>ApoE</i> Genotype on Response to Donepezil in Patients with Alzheimer’s Disease" @default.
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• W2079482822 doi "https://doi.org/10.1159/000124752" @default.
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• W2079482822 hasPublicationYear "2008" @default.
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