Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079484940> ?p ?o ?g. }
- W2079484940 endingPage "2620" @default.
- W2079484940 startingPage "2610" @default.
- W2079484940 abstract "The objective of this study was to design lipopolymers for hydrophobic drug delivery. Poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (PEG-PCD) lipopolymers were synthesized and characterized by (1)H NMR, FT-IR, GPC, and DSC. The critical micelle concentration (CMC) of PEG-PCD micelles was around 10(-8) M and decreased with increasing length of hydrophobic block. PEG-PCD micelles could efficiently load a model drug embelin into its hydrophobic core and significantly improve its solubility. The loading capacity was dependent on the polymer core structure, but the length of hydrophobic core had little effect. PEG-PCD formed both spherical and cylindrical micelles, which were dependent on the copolymer structure and composition. PEG-PCD lipopolymers with various hydrophobic core lengths showed similar drug release profiles, which were slower than that of poly(ethylene glycol)-block-poly(2-methyl-2-benzoxycarbonyl-propylene carbonate) (PEG-PBC) micelles. Embelin loaded PEG-PCD micelles showed significant inhibition of C4-2 prostate cancer cell proliferation, while no obvious cellular toxicity was observed for blank micelles." @default.
- W2079484940 created "2016-06-24" @default.
- W2079484940 creator A5040370583 @default.
- W2079484940 creator A5051052380 @default.
- W2079484940 creator A5082481540 @default.
- W2079484940 date "2010-08-30" @default.
- W2079484940 modified "2023-09-25" @default.
- W2079484940 title "Synthesis and Characterization of Amphiphilic Lipopolymers for Micellar Drug Delivery" @default.
- W2079484940 cites W1800156099 @default.
- W2079484940 cites W1963956640 @default.
- W2079484940 cites W1968143647 @default.
- W2079484940 cites W1971915206 @default.
- W2079484940 cites W1977977840 @default.
- W2079484940 cites W1980549030 @default.
- W2079484940 cites W1984295293 @default.
- W2079484940 cites W1985037778 @default.
- W2079484940 cites W1985631236 @default.
- W2079484940 cites W1985882425 @default.
- W2079484940 cites W1995232839 @default.
- W2079484940 cites W1997236997 @default.
- W2079484940 cites W2002516695 @default.
- W2079484940 cites W2010873143 @default.
- W2079484940 cites W2015346163 @default.
- W2079484940 cites W2017315930 @default.
- W2079484940 cites W2017747686 @default.
- W2079484940 cites W2032134888 @default.
- W2079484940 cites W2035320640 @default.
- W2079484940 cites W2038588448 @default.
- W2079484940 cites W2049236419 @default.
- W2079484940 cites W2050065138 @default.
- W2079484940 cites W2054934288 @default.
- W2079484940 cites W2057637635 @default.
- W2079484940 cites W2066284822 @default.
- W2079484940 cites W2068809055 @default.
- W2079484940 cites W2070633668 @default.
- W2079484940 cites W2081529909 @default.
- W2079484940 cites W2082138259 @default.
- W2079484940 cites W2083209388 @default.
- W2079484940 cites W2090127461 @default.
- W2079484940 cites W2090195146 @default.
- W2079484940 cites W2104558356 @default.
- W2079484940 cites W2136447069 @default.
- W2079484940 cites W2140835621 @default.
- W2079484940 cites W2145362882 @default.
- W2079484940 cites W2163887121 @default.
- W2079484940 cites W2164163240 @default.
- W2079484940 doi "https://doi.org/10.1021/bm100561v" @default.
- W2079484940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20804201" @default.
- W2079484940 hasPublicationYear "2010" @default.
- W2079484940 type Work @default.
- W2079484940 sameAs 2079484940 @default.
- W2079484940 citedByCount "114" @default.
- W2079484940 countsByYear W20794849402012 @default.
- W2079484940 countsByYear W20794849402013 @default.
- W2079484940 countsByYear W20794849402014 @default.
- W2079484940 countsByYear W20794849402015 @default.
- W2079484940 countsByYear W20794849402016 @default.
- W2079484940 countsByYear W20794849402017 @default.
- W2079484940 countsByYear W20794849402018 @default.
- W2079484940 countsByYear W20794849402019 @default.
- W2079484940 countsByYear W20794849402020 @default.
- W2079484940 countsByYear W20794849402021 @default.
- W2079484940 countsByYear W20794849402022 @default.
- W2079484940 countsByYear W20794849402023 @default.
- W2079484940 crossrefType "journal-article" @default.
- W2079484940 hasAuthorship W2079484940A5040370583 @default.
- W2079484940 hasAuthorship W2079484940A5051052380 @default.
- W2079484940 hasAuthorship W2079484940A5082481540 @default.
- W2079484940 hasConcept C10138342 @default.
- W2079484940 hasConcept C11268172 @default.
- W2079484940 hasConcept C127413603 @default.
- W2079484940 hasConcept C155574463 @default.
- W2079484940 hasConcept C15920480 @default.
- W2079484940 hasConcept C162324750 @default.
- W2079484940 hasConcept C178790620 @default.
- W2079484940 hasConcept C184651966 @default.
- W2079484940 hasConcept C185592680 @default.
- W2079484940 hasConcept C188027245 @default.
- W2079484940 hasConcept C2777516009 @default.
- W2079484940 hasConcept C2779820397 @default.
- W2079484940 hasConcept C42360764 @default.
- W2079484940 hasConcept C521977710 @default.
- W2079484940 hasConcept C54400483 @default.
- W2079484940 hasConcept C64237528 @default.
- W2079484940 hasConcept C67407626 @default.
- W2079484940 hasConceptScore W2079484940C10138342 @default.
- W2079484940 hasConceptScore W2079484940C11268172 @default.
- W2079484940 hasConceptScore W2079484940C127413603 @default.
- W2079484940 hasConceptScore W2079484940C155574463 @default.
- W2079484940 hasConceptScore W2079484940C15920480 @default.
- W2079484940 hasConceptScore W2079484940C162324750 @default.
- W2079484940 hasConceptScore W2079484940C178790620 @default.
- W2079484940 hasConceptScore W2079484940C184651966 @default.
- W2079484940 hasConceptScore W2079484940C185592680 @default.
- W2079484940 hasConceptScore W2079484940C188027245 @default.
- W2079484940 hasConceptScore W2079484940C2777516009 @default.
- W2079484940 hasConceptScore W2079484940C2779820397 @default.
- W2079484940 hasConceptScore W2079484940C42360764 @default.