FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079485023> ?p ?o ?g. }

• W2079485023 endingPage "1910" @default.
• W2079485023 startingPage "1892" @default.
• W2079485023 abstract "ABSTRACT Human parainfluenza virus type 1 (HPIV1) is an important respiratory pathogen in children and the most common cause of viral croup. We performed a microarray-based analysis of gene expression kinetics to examine how wild-type (wt) HPIV1 infection altered gene expression in human respiratory epithelial cells and what role beta interferon played in this response. We similarly evaluated HPIV1-P(C−), a highly attenuated and apoptosis-inducing virus that does not express any of the four C proteins, and HPIV1-C F170S , a less attenuated mutant that contains a single point mutation in C and, like wt HPIV1, does not efficiently induce apoptosis, to examine the role of the C proteins in controlling host gene expression. We also used these data to investigate whether the phenotypic differences between the two C mutants could be explained at the transcriptional level. Mutation or deletion of the C proteins of HPIV1 permitted the activation of over 2,000 cellular genes that otherwise would be repressed by HPIV1 infection. Thus, the C proteins profoundly suppress the response of human respiratory cells to HPIV1 infection. Cellular pathways targeted by the HPIV1 C proteins were identified and their transcriptional control was analyzed using bioinformatics. Transcription factor binding sites for IRF and NF-κB were overrepresented in some of the C protein-targeted pathways, but other pathways were dominated by less-known factors, such as forkhead transcription factor FOXD1. Surprisingly, the host responses to the P(C−) and C F170S mutants were very similar, and only subtle differences in the expression kinetics of caspase 3 and TRAIL receptor 2 were observed. Thus, changes in host cell transcription did not reflect the striking phenotypic differences observed between these two viruses." @default.
• W2079485023 created "2016-06-24" @default.
• W2079485023 creator A5001806740 @default.
• W2079485023 creator A5027582911 @default.
• W2079485023 creator A5034896027 @default.
• W2079485023 creator A5040448085 @default.
• W2079485023 creator A5062733502 @default.
• W2079485023 creator A5087874713 @default.
• W2079485023 date "2009-02-15" @default.
• W2079485023 modified "2023-10-10" @default.
• W2079485023 title "The C Proteins of Human Parainfluenza Virus Type 1 (HPIV1) Control the Transcription of a Broad Array of Cellular Genes That Would Otherwise Respond to HPIV1 Infection" @default.
• W2079485023 cites W1490458608 @default.
• W2079485023 cites W1498146886 @default.
• W2079485023 cites W1499648698 @default.
• W2079485023 cites W1524354116 @default.
• W2079485023 cites W1567793583 @default.
• W2079485023 cites W1596639944 @default.
• W2079485023 cites W1966820106 @default.
• W2079485023 cites W1976637392 @default.
• W2079485023 cites W1980986239 @default.
• W2079485023 cites W1983668987 @default.
• W2079485023 cites W1993021726 @default.
• W2079485023 cites W1997099619 @default.
• W2079485023 cites W2004995275 @default.
• W2079485023 cites W2005019213 @default.
• W2079485023 cites W2009127910 @default.
• W2079485023 cites W2010091770 @default.
• W2079485023 cites W2013601771 @default.
• W2079485023 cites W2015149829 @default.
• W2079485023 cites W2017515700 @default.
• W2079485023 cites W2018828712 @default.
• W2079485023 cites W2021179127 @default.
• W2079485023 cites W2025289680 @default.
• W2079485023 cites W2028575270 @default.
• W2079485023 cites W2031163071 @default.
• W2079485023 cites W2032549397 @default.
• W2079485023 cites W2036293436 @default.
• W2079485023 cites W2048664619 @default.
• W2079485023 cites W2052501023 @default.
• W2079485023 cites W2062154149 @default.
• W2079485023 cites W2062490839 @default.
• W2079485023 cites W2063082801 @default.
• W2079485023 cites W2063114480 @default.
• W2079485023 cites W2063887176 @default.
• W2079485023 cites W2067263136 @default.
• W2079485023 cites W2075413744 @default.
• W2079485023 cites W2076361525 @default.
• W2079485023 cites W2076710809 @default.
• W2079485023 cites W2081514938 @default.
• W2079485023 cites W2084620487 @default.
• W2079485023 cites W2088534886 @default.
• W2079485023 cites W2089077517 @default.
• W2079485023 cites W2089194065 @default.
• W2079485023 cites W2091753360 @default.
• W2079485023 cites W2101183705 @default.
• W2079485023 cites W2106587802 @default.
• W2079485023 cites W2107513655 @default.
• W2079485023 cites W2108244474 @default.
• W2079485023 cites W2111247784 @default.
• W2079485023 cites W2113833510 @default.
• W2079485023 cites W2114737175 @default.
• W2079485023 cites W2124358132 @default.
• W2079485023 cites W2132975022 @default.
• W2079485023 cites W2136920638 @default.
• W2079485023 cites W2137303998 @default.
• W2079485023 cites W2137627132 @default.
• W2079485023 cites W2139332922 @default.
• W2079485023 cites W2140353888 @default.
• W2079485023 cites W2141137217 @default.
• W2079485023 cites W2141266091 @default.
• W2079485023 cites W2142176622 @default.
• W2079485023 cites W2144705443 @default.
• W2079485023 cites W2144857397 @default.
• W2079485023 cites W2150926065 @default.
• W2079485023 cites W2154530515 @default.
• W2079485023 cites W2157395311 @default.
• W2079485023 cites W2160063406 @default.
• W2079485023 cites W2160999690 @default.
• W2079485023 cites W2169433551 @default.
• W2079485023 cites W2170643754 @default.
• W2079485023 cites W2184414598 @default.
• W2079485023 doi "https://doi.org/10.1128/jvi.01373-08" @default.
• W2079485023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2643784" @default.
• W2079485023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19052086" @default.
• W2079485023 hasPublicationYear "2009" @default.
• W2079485023 type Work @default.
• W2079485023 sameAs 2079485023 @default.
• W2079485023 citedByCount "14" @default.
• W2079485023 countsByYear W20794850232012 @default.
• W2079485023 countsByYear W20794850232013 @default.
• W2079485023 countsByYear W20794850232014 @default.
• W2079485023 countsByYear W20794850232020 @default.
• W2079485023 crossrefType "journal-article" @default.
• W2079485023 hasAuthorship W2079485023A5001806740 @default.
• W2079485023 hasAuthorship W2079485023A5027582911 @default.
• W2079485023 hasAuthorship W2079485023A5034896027 @default.
• W2079485023 hasAuthorship W2079485023A5040448085 @default.
• W2079485023 hasAuthorship W2079485023A5062733502 @default.

• next