FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079488932> ?p ?o ?g. }

• W2079488932 endingPage "236" @default.
• W2079488932 startingPage "230" @default.
• W2079488932 abstract "Pigeon intestinal mucin, a complex high molecular weight glycoprotein, is a key antigen in the development of pigeon fanciers' lung (PFL). We have studied the specificity of antibodies to mucin in patients with PFL and asymptomatic antibody-positive individuals. Extensive papain digestion, which removes the non-glycosylated regions of the mucin leaving the heavily glycosylated 'bottle brush' regions, resulted in a 600-fold decrease in IgG3 antibody titres with little effect on IgG1 and IgG2 titres. This suggests that IgG1 and IgG2 are directed against the region rich in O-linked sugar chains whilst the majority of the IgG3 is directed against epitopes which are proteinase-sensitive. Lectin mapping of the carbohydrates present on pigeon intestinal mucin demonstrated high levels of exposed N-acetyl neuraminic acid, N-acetyl galactosamine and N-acetyl glucosamine, with lower levels of fucose and some galactose. Sera from pigeon fanciers inhibited binding of lectins specific for N-acetyl neuraminic acid, N-acetyl galactosamine, internal N-acetyl glucosamine and fucose. Sera from people with PFL, compared with sera from asymptomatic antibody-positive fanciers, had significantly higher titres of antibody that inhibited binding of four lectins specific for N-acetyl galactosamine and one fucose-specific lectin, suggesting that these sugars may play a dominant role in disease-associated epitopes. The results suggest that different IgG subclasses recognize different epitopes on mucin and that the epitopes recognized by the major subclasses are present on the O-linked oligosaccharides. Further, the carbohydrate-specific anti-mucin antibodies produced by PFL patients may differ in their specificity from those found in asymptomatic individuals." @default.
• W2079488932 created "2016-06-24" @default.
• W2079488932 creator A5006014772 @default.
• W2079488932 creator A5008976051 @default.
• W2079488932 creator A5042223719 @default.
• W2079488932 creator A5060206174 @default.
• W2079488932 creator A5086608524 @default.
• W2079488932 date "1999-08-01" @default.
• W2079488932 modified "2023-10-16" @default.
• W2079488932 title "Pigeon fanciers' lung: identification of disease-associated carbohydrate epitopes on pigeon intestinal mucin" @default.
• W2079488932 cites W104613884 @default.
• W2079488932 cites W1538872196 @default.
• W2079488932 cites W1569726016 @default.
• W2079488932 cites W1607163851 @default.
• W2079488932 cites W1966526066 @default.
• W2079488932 cites W1971715069 @default.
• W2079488932 cites W1973556628 @default.
• W2079488932 cites W1981549820 @default.
• W2079488932 cites W1988422289 @default.
• W2079488932 cites W1990035528 @default.
• W2079488932 cites W1990551876 @default.
• W2079488932 cites W1992042749 @default.
• W2079488932 cites W1995466057 @default.
• W2079488932 cites W2001913452 @default.
• W2079488932 cites W2021659699 @default.
• W2079488932 cites W2035269991 @default.
• W2079488932 cites W2038446694 @default.
• W2079488932 cites W2054026083 @default.
• W2079488932 cites W2058398420 @default.
• W2079488932 cites W2062048878 @default.
• W2079488932 cites W2066509542 @default.
• W2079488932 cites W2069528996 @default.
• W2079488932 cites W2089618341 @default.
• W2079488932 cites W2104022144 @default.
• W2079488932 cites W2106250351 @default.
• W2079488932 cites W2398718215 @default.
• W2079488932 cites W2399895279 @default.
• W2079488932 cites W2403254693 @default.
• W2079488932 cites W2416901634 @default.
• W2079488932 cites W66715201 @default.
• W2079488932 cites W6725611 @default.
• W2079488932 doi "https://doi.org/10.1046/j.1365-2249.1999.00981.x" @default.
• W2079488932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1905352" @default.
• W2079488932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10444252" @default.
• W2079488932 hasPublicationYear "1999" @default.
• W2079488932 type Work @default.
• W2079488932 sameAs 2079488932 @default.
• W2079488932 citedByCount "17" @default.
• W2079488932 countsByYear W20794889322013 @default.
• W2079488932 countsByYear W20794889322016 @default.
• W2079488932 countsByYear W20794889322017 @default.
• W2079488932 countsByYear W20794889322020 @default.
• W2079488932 countsByYear W20794889322022 @default.
• W2079488932 crossrefType "journal-article" @default.
• W2079488932 hasAuthorship W2079488932A5006014772 @default.
• W2079488932 hasAuthorship W2079488932A5008976051 @default.
• W2079488932 hasAuthorship W2079488932A5042223719 @default.
• W2079488932 hasAuthorship W2079488932A5060206174 @default.
• W2079488932 hasAuthorship W2079488932A5086608524 @default.
• W2079488932 hasBestOaLocation W20794889322 @default.
• W2079488932 hasConcept C108625454 @default.
• W2079488932 hasConcept C147483822 @default.
• W2079488932 hasConcept C159654299 @default.
• W2079488932 hasConcept C179264091 @default.
• W2079488932 hasConcept C195616568 @default.
• W2079488932 hasConcept C203014093 @default.
• W2079488932 hasConcept C2776841590 @default.
• W2079488932 hasConcept C2778125326 @default.
• W2079488932 hasConcept C2780115458 @default.
• W2079488932 hasConcept C2780758401 @default.
• W2079488932 hasConcept C2781302033 @default.
• W2079488932 hasConcept C2781467277 @default.
• W2079488932 hasConcept C55493867 @default.
• W2079488932 hasConcept C86803240 @default.
• W2079488932 hasConceptScore W2079488932C108625454 @default.
• W2079488932 hasConceptScore W2079488932C147483822 @default.
• W2079488932 hasConceptScore W2079488932C159654299 @default.
• W2079488932 hasConceptScore W2079488932C179264091 @default.
• W2079488932 hasConceptScore W2079488932C195616568 @default.
• W2079488932 hasConceptScore W2079488932C203014093 @default.
• W2079488932 hasConceptScore W2079488932C2776841590 @default.
• W2079488932 hasConceptScore W2079488932C2778125326 @default.
• W2079488932 hasConceptScore W2079488932C2780115458 @default.
• W2079488932 hasConceptScore W2079488932C2780758401 @default.
• W2079488932 hasConceptScore W2079488932C2781302033 @default.
• W2079488932 hasConceptScore W2079488932C2781467277 @default.
• W2079488932 hasConceptScore W2079488932C55493867 @default.
• W2079488932 hasConceptScore W2079488932C86803240 @default.
• W2079488932 hasIssue "2" @default.
• W2079488932 hasLocation W20794889321 @default.
• W2079488932 hasLocation W20794889322 @default.
• W2079488932 hasLocation W20794889323 @default.
• W2079488932 hasOpenAccess W2079488932 @default.
• W2079488932 hasPrimaryLocation W20794889321 @default.
• W2079488932 hasRelatedWork W1512071113 @default.
• W2079488932 hasRelatedWork W1932028648 @default.
• W2079488932 hasRelatedWork W2013202895 @default.
• W2079488932 hasRelatedWork W2037124093 @default.

• next