FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079489804> ?p ?o ?g. }

• W2079489804 endingPage "909" @default.
• W2079489804 startingPage "901" @default.
• W2079489804 abstract "Although endocannabinoid anandamide (AEA) plays an important role in synaptic signaling and neuronal survival, the underlying mechanism is not fully understood. Afterhyperpolarization (AHP) is the critical modulator of cell excitability and in turn shapes the neuronal output. Here, we examined the effects of AEA on AHP current and action potential firing in cultured rat hippocampal neurons. In whole-cell patch-clamp recording, AEA applied in the extracellular medium at nanomolar concentration enhanced medium AHP (mAHP) current and spike-frequency adaptation. Activation of apamin-sensitive, small conductance Ca2+-activated K+ (SK) channels, probably SK2 and SK3 as the immunofluorescence analysis indicated, attributed largely to the AEA action on mAHP. Interestingly, AEA-induced potentiation of mAHP current was abolished by inositol 1,4,5-trisphosphate receptors (IP3Rs) blockade. However, the potentiation was not affected by inhibiting Ca2+ influx or Ca2+ release from internal store through ryanodine receptors. In addition, blockade of CB1, TRPV1 or Gi/o-protein did not attenuate the potentiation. Thus, AEA might enhance the SK mAHP currents mainly in a non-CB1/TRPV1 receptor way. Our study provides the first evidence that a functional cascade might lie among AEA, IP3Rs and SK channels, which may keep the membrane excitability stable in a negative-feedback manner." @default.
• W2079489804 created "2016-06-24" @default.
• W2079489804 creator A5001621109 @default.
• W2079489804 creator A5012587170 @default.
• W2079489804 creator A5016038041 @default.
• W2079489804 creator A5018700169 @default.
• W2079489804 creator A5029258954 @default.
• W2079489804 creator A5046597133 @default.
• W2079489804 creator A5057128346 @default.
• W2079489804 date "2011-05-01" @default.
• W2079489804 modified "2023-09-27" @default.
• W2079489804 title "Enhancement of apamin-sensitive medium afterhyperpolarization current by anandamide and its role in excitability control in cultured hippocampal neurons" @default.
• W2079489804 cites W1490982132 @default.
• W2079489804 cites W1543340594 @default.
• W2079489804 cites W1975025750 @default.
• W2079489804 cites W1976127510 @default.
• W2079489804 cites W1989073099 @default.
• W2079489804 cites W1991890788 @default.
• W2079489804 cites W1993881834 @default.
• W2079489804 cites W1996176484 @default.
• W2079489804 cites W2002797425 @default.
• W2079489804 cites W2006839087 @default.
• W2079489804 cites W2007578821 @default.
• W2079489804 cites W2058766482 @default.
• W2079489804 cites W2065693649 @default.
• W2079489804 cites W2068389305 @default.
• W2079489804 cites W2082433795 @default.
• W2079489804 cites W2083925864 @default.
• W2079489804 cites W2087371496 @default.
• W2079489804 cites W2091263028 @default.
• W2079489804 cites W2092395287 @default.
• W2079489804 cites W2094213154 @default.
• W2079489804 cites W2100784365 @default.
• W2079489804 cites W2103156942 @default.
• W2079489804 cites W2109279225 @default.
• W2079489804 cites W2119397841 @default.
• W2079489804 cites W2125556242 @default.
• W2079489804 cites W2144957675 @default.
• W2079489804 cites W2163577791 @default.
• W2079489804 cites W2165013954 @default.
• W2079489804 cites W2165518874 @default.
• W2079489804 cites W2166017636 @default.
• W2079489804 cites W2170538656 @default.
• W2079489804 cites W2171335874 @default.
• W2079489804 doi "https://doi.org/10.1016/j.neuropharm.2011.01.027" @default.
• W2079489804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21272594" @default.
• W2079489804 hasPublicationYear "2011" @default.
• W2079489804 type Work @default.
• W2079489804 sameAs 2079489804 @default.
• W2079489804 citedByCount "14" @default.
• W2079489804 countsByYear W20794898042012 @default.
• W2079489804 countsByYear W20794898042013 @default.
• W2079489804 countsByYear W20794898042014 @default.
• W2079489804 countsByYear W20794898042015 @default.
• W2079489804 countsByYear W20794898042016 @default.
• W2079489804 countsByYear W20794898042017 @default.
• W2079489804 countsByYear W20794898042019 @default.
• W2079489804 countsByYear W20794898042021 @default.
• W2079489804 crossrefType "journal-article" @default.
• W2079489804 hasAuthorship W2079489804A5001621109 @default.
• W2079489804 hasAuthorship W2079489804A5012587170 @default.
• W2079489804 hasAuthorship W2079489804A5016038041 @default.
• W2079489804 hasAuthorship W2079489804A5018700169 @default.
• W2079489804 hasAuthorship W2079489804A5029258954 @default.
• W2079489804 hasAuthorship W2079489804A5046597133 @default.
• W2079489804 hasAuthorship W2079489804A5057128346 @default.
• W2079489804 hasConcept C126322002 @default.
• W2079489804 hasConcept C134018914 @default.
• W2079489804 hasConcept C148001335 @default.
• W2079489804 hasConcept C148762608 @default.
• W2079489804 hasConcept C169760540 @default.
• W2079489804 hasConcept C170493617 @default.
• W2079489804 hasConcept C185592680 @default.
• W2079489804 hasConcept C25274449 @default.
• W2079489804 hasConcept C2776885963 @default.
• W2079489804 hasConcept C2776919887 @default.
• W2079489804 hasConcept C2779783865 @default.
• W2079489804 hasConcept C55493867 @default.
• W2079489804 hasConcept C71924100 @default.
• W2079489804 hasConcept C83743174 @default.
• W2079489804 hasConcept C86803240 @default.
• W2079489804 hasConcept C93872552 @default.
• W2079489804 hasConceptScore W2079489804C126322002 @default.
• W2079489804 hasConceptScore W2079489804C134018914 @default.
• W2079489804 hasConceptScore W2079489804C148001335 @default.
• W2079489804 hasConceptScore W2079489804C148762608 @default.
• W2079489804 hasConceptScore W2079489804C169760540 @default.
• W2079489804 hasConceptScore W2079489804C170493617 @default.
• W2079489804 hasConceptScore W2079489804C185592680 @default.
• W2079489804 hasConceptScore W2079489804C25274449 @default.
• W2079489804 hasConceptScore W2079489804C2776885963 @default.
• W2079489804 hasConceptScore W2079489804C2776919887 @default.
• W2079489804 hasConceptScore W2079489804C2779783865 @default.
• W2079489804 hasConceptScore W2079489804C55493867 @default.
• W2079489804 hasConceptScore W2079489804C71924100 @default.
• W2079489804 hasConceptScore W2079489804C83743174 @default.
• W2079489804 hasConceptScore W2079489804C86803240 @default.
• W2079489804 hasConceptScore W2079489804C93872552 @default.

• next