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- W2079493312 abstract "Effects of odorants on a delayed rectifier potassium current (IK) in newt olfactory receptor cells (ORCs) were investigated using the whole-cell version of the patch-clamp technique. Under voltage clamp, odorants (amyl acetate, limonene and acetophenone) reversibly suppressed IK without shifting its I–V curve. An amyl acetate puff completely suppressed IK induced by the first step pulse of repetitive depolarizations, suggesting that binding of an odorant molecule to the open channel is not required to block the channel. Although it is known that odorants suppress Na+ and Ca2+ currents (INa, ICa) by shifting their inactivation curves to a negative voltage, odorants did not shift the inactivation curve of IK significantly. This suggests that odorants suppress IK without changing its voltage dependence. Therefore, the blocking mechanisms by odorants of IK in ORCs are different from those of INa and ICa." @default.
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- W2079493312 date "1999-07-01" @default.
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- W2079493312 title "Odorant suppression of delayed rectifier potassium current in newt olfactory receptor cells" @default.
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- W2079493312 doi "https://doi.org/10.1016/s0304-3940(99)00424-3" @default.
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