Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079494009> ?p ?o ?g. }
- W2079494009 endingPage "876" @default.
- W2079494009 startingPage "867" @default.
- W2079494009 abstract "Abstract Colon‐residing bacteria, such as vancomycin‐resistant Enterococcus faecalis and Bacteroides fragilis , can cause a range of serious clinical infections. Photodynamic antimicrobial chemotherapy (PACT) may be a novel treatment option for these multidrug resistant organisms. The aim of this study was to formulate a Eudragit ® ‐based drug delivery system, via hot melt extrusion (HME), for targeting colonic release of photosensitizer. The susceptibility of E. faecalis and B. fragilis to PACT mediated by methylene blue (MB), meso‐tetra(N‐methyl‐4‐pyridyl)porphine tetra‐tosylate (TMP), or 5‐aminolevulinic acid hexyl‐ester (h‐ALA) was determined, with tetrachlorodecaoxide (TCDO), an oxygen‐releasing compound, added in some studies. Results show that, for MB, an average of 30% of the total drug load was released over a 6‐h period. For TMP and h‐ALA, these values were 50% and 16% respectively. No drug was released in the acidic media. Levels of E. faecalis and B. fragilis were reduced by up to 4.67 and 7.73 logs, respectively, on PACT exposure under anaerobic conditions, with increased kill associated with TCDO. With these formulations, photosensitizer release could potentially be targeted to the colon, and colon‐residing pathogens killed by PACT. TCDO could be used in vivo to generate oxygen, which could significantly impact on the success of PACT in the clinic." @default.
- W2079494009 created "2016-06-24" @default.
- W2079494009 creator A5002560446 @default.
- W2079494009 creator A5035668087 @default.
- W2079494009 creator A5051196293 @default.
- W2079494009 creator A5052945060 @default.
- W2079494009 creator A5070656738 @default.
- W2079494009 date "2011-04-06" @default.
- W2079494009 modified "2023-10-16" @default.
- W2079494009 title "Development of Novel Oral Formulations Prepared <i>via</i> Hot Melt Extrusion for Targeted Delivery of Photosensitizer to the Colon" @default.
- W2079494009 cites W1511449683 @default.
- W2079494009 cites W1904634031 @default.
- W2079494009 cites W1964464141 @default.
- W2079494009 cites W1970387954 @default.
- W2079494009 cites W1974526844 @default.
- W2079494009 cites W1979555303 @default.
- W2079494009 cites W1988053043 @default.
- W2079494009 cites W1989806930 @default.
- W2079494009 cites W1995143361 @default.
- W2079494009 cites W2006682190 @default.
- W2079494009 cites W2008777828 @default.
- W2079494009 cites W2011471424 @default.
- W2079494009 cites W2013523598 @default.
- W2079494009 cites W2013594810 @default.
- W2079494009 cites W2014300869 @default.
- W2079494009 cites W2014769332 @default.
- W2079494009 cites W2017821807 @default.
- W2079494009 cites W2019019053 @default.
- W2079494009 cites W2019098068 @default.
- W2079494009 cites W2030168336 @default.
- W2079494009 cites W2030841219 @default.
- W2079494009 cites W2031848920 @default.
- W2079494009 cites W2040010886 @default.
- W2079494009 cites W2042974423 @default.
- W2079494009 cites W2044883409 @default.
- W2079494009 cites W2046897703 @default.
- W2079494009 cites W2055273488 @default.
- W2079494009 cites W2057689371 @default.
- W2079494009 cites W2060320802 @default.
- W2079494009 cites W2062290043 @default.
- W2079494009 cites W2064238170 @default.
- W2079494009 cites W2065433813 @default.
- W2079494009 cites W2074564345 @default.
- W2079494009 cites W2081405316 @default.
- W2079494009 cites W2082868197 @default.
- W2079494009 cites W2082926225 @default.
- W2079494009 cites W2088388858 @default.
- W2079494009 cites W2094190392 @default.
- W2079494009 cites W2100961929 @default.
- W2079494009 cites W2109966571 @default.
- W2079494009 cites W2112434786 @default.
- W2079494009 cites W2113876632 @default.
- W2079494009 cites W2115439624 @default.
- W2079494009 cites W2118436621 @default.
- W2079494009 cites W2121937028 @default.
- W2079494009 cites W2126293994 @default.
- W2079494009 cites W2128778400 @default.
- W2079494009 cites W2128965682 @default.
- W2079494009 cites W2132193279 @default.
- W2079494009 cites W2135375882 @default.
- W2079494009 cites W2137199367 @default.
- W2079494009 cites W2137555928 @default.
- W2079494009 cites W2145802125 @default.
- W2079494009 cites W2145817077 @default.
- W2079494009 cites W2148504718 @default.
- W2079494009 cites W2153933922 @default.
- W2079494009 cites W2285001202 @default.
- W2079494009 cites W4242580704 @default.
- W2079494009 cites W4249253434 @default.
- W2079494009 doi "https://doi.org/10.1111/j.1751-1097.2011.00915.x" @default.
- W2079494009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21375536" @default.
- W2079494009 hasPublicationYear "2011" @default.
- W2079494009 type Work @default.
- W2079494009 sameAs 2079494009 @default.
- W2079494009 citedByCount "23" @default.
- W2079494009 countsByYear W20794940092012 @default.
- W2079494009 countsByYear W20794940092013 @default.
- W2079494009 countsByYear W20794940092014 @default.
- W2079494009 countsByYear W20794940092015 @default.
- W2079494009 countsByYear W20794940092016 @default.
- W2079494009 countsByYear W20794940092019 @default.
- W2079494009 countsByYear W20794940092020 @default.
- W2079494009 countsByYear W20794940092021 @default.
- W2079494009 countsByYear W20794940092022 @default.
- W2079494009 countsByYear W20794940092023 @default.
- W2079494009 crossrefType "journal-article" @default.
- W2079494009 hasAuthorship W2079494009A5002560446 @default.
- W2079494009 hasAuthorship W2079494009A5035668087 @default.
- W2079494009 hasAuthorship W2079494009A5051196293 @default.
- W2079494009 hasAuthorship W2079494009A5052945060 @default.
- W2079494009 hasAuthorship W2079494009A5070656738 @default.
- W2079494009 hasConcept C104317684 @default.
- W2079494009 hasConcept C150903083 @default.
- W2079494009 hasConcept C161790260 @default.
- W2079494009 hasConcept C166957645 @default.
- W2079494009 hasConcept C178790620 @default.
- W2079494009 hasConcept C185592680 @default.
- W2079494009 hasConcept C207001950 @default.