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- W2079496685 abstract "Summary The number of mast cells found per transverse section of uteri taken from intact rats was lower in estrus (5.8 cells) than in diestrus (11.7 cells); cell counts in ovariectomized rats more closely approximated those in estrus animals. Treatment of ovariectomized rats with a single dose of estradiol (0.5 μg/100 g body weight) or cortisol did not significantly change the number of mast cells in uterus, mesometrium or skin within 24 hr. Unlike metachromatic material in mast cells elsewhere in the body, that in uterine and mesometrial cells occurs in a diffuse, hyalin form and rarely as discrete granules. These observations are discussed in relation to previously reported findings that estrogen stimulates release of histamine from the rat uterus. If it can be assumed that mast cells are the estrogen-sensitive repositories of histamine, failure to detect cytological changes in the present experiments after treatment with exogenous hormones suggests that release of the amine from mast cells of the rat uterus or mesometrium is merocrine or holocrine in nature depending on dosage and duration of hormone treatment. Alternatively, estrogen may activate uterine sites of histamine synthesis and storage other than mast cells." @default.
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- W2079496685 date "1966-01-01" @default.
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- W2079496685 title "The effects of estradiol on the occurrence of mast cells in the rat uterus" @default.
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- W2079496685 doi "https://doi.org/10.1016/s0014-4827(66)80131-3" @default.
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