FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079497611> ?p ?o ?g. }

• W2079497611 endingPage "2349" @default.
• W2079497611 startingPage "2336" @default.
• W2079497611 abstract "We report cloning, pharmacological characterization, tissue distribution, detailed brain mapping, and role in control of food intake of melanocortin 4 receptor in goldfish (gMC4R). The gMC4R protein has 68% identity with the human ortholog and is conserved in important functional domains. Pharmacological profiling showed similar affinities and potency order to hMC4R for MSH peptides, whereas MTII and HS024 were identified as high-affinity agonist and antagonist analogs, respectively. The gMC4R-mRNA was found in brain and some peripheral tissues including the ovary, gill, and spleen. Detailed MC4R-mRNA mapping showed expression in main neuroendocrine and food intake-controlling areas. High expression levels were found in the telencephalon, preoptic area, ventral thalamus, tuberal hypothalamus, and hypothalamic inferior lobe. By RT-PCR, low levels were also detected in the cerebellum, medulla, and spinal cord. Intracerebroventricular MTII administration inhibited food intake in 24-h fasted animals in a dose-dependent manner, whereas HS024 stimulated food intake in fed animals, suggesting that melanocortins exert a tonic inhibitory effect on food intake, which is mediated through central MC4R signaling. The conserved central expression pattern and physiological role in regulation of food intake for the MC4R suggests that neuronal pathways of the melanocortin system may be important for regulation of energy homeostasis in most vertebrates." @default.
• W2079497611 created "2016-06-24" @default.
• W2079497611 creator A5010183444 @default.
• W2079497611 creator A5014642344 @default.
• W2079497611 creator A5079833269 @default.
• W2079497611 creator A5085396890 @default.
• W2079497611 date "2003-06-01" @default.
• W2079497611 modified "2023-10-01" @default.
• W2079497611 title "Molecular Cloning, Pharmacological Characterization, and Brain Mapping of the Melanocortin 4 Receptor in the Goldfish: Involvement in the Control of Food Intake" @default.
• W2079497611 cites W1488596761 @default.
• W2079497611 cites W1549372716 @default.
• W2079497611 cites W1557479171 @default.
• W2079497611 cites W1572502886 @default.
• W2079497611 cites W1779019576 @default.
• W2079497611 cites W1965925588 @default.
• W2079497611 cites W1966841534 @default.
• W2079497611 cites W1967863599 @default.
• W2079497611 cites W1973772334 @default.
• W2079497611 cites W1976640392 @default.
• W2079497611 cites W1980392808 @default.
• W2079497611 cites W1980812867 @default.
• W2079497611 cites W1984061089 @default.
• W2079497611 cites W1984519863 @default.
• W2079497611 cites W1985178630 @default.
• W2079497611 cites W1994957236 @default.
• W2079497611 cites W1996250291 @default.
• W2079497611 cites W2006849207 @default.
• W2079497611 cites W2007919092 @default.
• W2079497611 cites W2008162623 @default.
• W2079497611 cites W2010142606 @default.
• W2079497611 cites W2017690914 @default.
• W2079497611 cites W2025546412 @default.
• W2079497611 cites W2031368311 @default.
• W2079497611 cites W2032415044 @default.
• W2079497611 cites W2032444295 @default.
• W2079497611 cites W2041531639 @default.
• W2079497611 cites W2055517784 @default.
• W2079497611 cites W2062294807 @default.
• W2079497611 cites W2062887087 @default.
• W2079497611 cites W2065389660 @default.
• W2079497611 cites W2076915514 @default.
• W2079497611 cites W2083116048 @default.
• W2079497611 cites W2083273034 @default.
• W2079497611 cites W2084547258 @default.
• W2079497611 cites W2086787762 @default.
• W2079497611 cites W2087299407 @default.
• W2079497611 cites W2090460315 @default.
• W2079497611 cites W2090674067 @default.
• W2079497611 cites W2098877379 @default.
• W2079497611 cites W2105470099 @default.
• W2079497611 cites W2122223920 @default.
• W2079497611 cites W2136061619 @default.
• W2079497611 cites W2140850665 @default.
• W2079497611 cites W2146423242 @default.
• W2079497611 cites W2150093846 @default.
• W2079497611 cites W2161430633 @default.
• W2079497611 cites W2164894105 @default.
• W2079497611 cites W2166357316 @default.
• W2079497611 cites W2171010063 @default.
• W2079497611 doi "https://doi.org/10.1210/en.2002-0213" @default.
• W2079497611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12746294" @default.
• W2079497611 hasPublicationYear "2003" @default.
• W2079497611 type Work @default.
• W2079497611 sameAs 2079497611 @default.
• W2079497611 citedByCount "153" @default.
• W2079497611 countsByYear W20794976112012 @default.
• W2079497611 countsByYear W20794976112013 @default.
• W2079497611 countsByYear W20794976112014 @default.
• W2079497611 countsByYear W20794976112015 @default.
• W2079497611 countsByYear W20794976112016 @default.
• W2079497611 countsByYear W20794976112017 @default.
• W2079497611 countsByYear W20794976112018 @default.
• W2079497611 countsByYear W20794976112019 @default.
• W2079497611 countsByYear W20794976112020 @default.
• W2079497611 countsByYear W20794976112021 @default.
• W2079497611 countsByYear W20794976112022 @default.
• W2079497611 countsByYear W20794976112023 @default.
• W2079497611 crossrefType "journal-article" @default.
• W2079497611 hasAuthorship W2079497611A5010183444 @default.
• W2079497611 hasAuthorship W2079497611A5014642344 @default.
• W2079497611 hasAuthorship W2079497611A5079833269 @default.
• W2079497611 hasAuthorship W2079497611A5085396890 @default.
• W2079497611 hasBestOaLocation W20794976111 @default.
• W2079497611 hasConcept C126322002 @default.
• W2079497611 hasConcept C134018914 @default.
• W2079497611 hasConcept C170493617 @default.
• W2079497611 hasConcept C2491326 @default.
• W2079497611 hasConcept C2777003273 @default.
• W2079497611 hasConcept C2777241137 @default.
• W2079497611 hasConcept C2778938600 @default.
• W2079497611 hasConcept C2779993316 @default.
• W2079497611 hasConcept C2909567013 @default.
• W2079497611 hasConcept C43295716 @default.
• W2079497611 hasConcept C43790157 @default.
• W2079497611 hasConcept C511355011 @default.
• W2079497611 hasConcept C529278444 @default.
• W2079497611 hasConcept C533869091 @default.
• W2079497611 hasConcept C71315377 @default.

• next