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• W2079498453 abstract "Background In the failing human heart myofibrillar calcium sensitivity of tension development is greater and maximal myofibrillar ATPase activity is less than in the normal heart. Phosphorylation of the cardiac troponin I (cTnI)–specific NH 2 -terminus decreases myofilament sensitivity to calcium, while phosphorylation of other cTnI sites decreases maximal myofibrillar ATPase activity. Methods and Results We examined cTnI phosphorylation in left ventricular myocardium collected from failing hearts at the time of transplant (n=20) and normal hearts from trauma victims (n=24). The relative amounts of actin, tropomyosin, and TnI did not differ between failing and normal myocardium. Using Western blot analysis with a monoclonal antibody (MAb) that recognizes the striated muscle TnI isoforms, we confirmed that the adult human heart expresses only cTnI. A cTnI-specific MAb recognized two bands of cTnI, designated cTnI 1 and cTnI 2 , while a MAb whose epitope is located in the cTnI-specific NH 2 -terminus recognized only cTnI 1 . Alkaline phosphatase decreased the relative amount of cTnI 1 , while protein kinase A and protein kinase C increased cTnI 1 . The percentage of cTnI made up of cTnI 1 , the phosphorylated form of TnI, is greater in the normal than the failing human heart ( P <.001). Conclusions This phosphorylation difference could underlie the reported greater myofibrillar calcium sensitivity of failing myocardium. The functional consequence of this difference may be an adaptive or maladaptive response to the lower and longer calcium concentration transient of the failing heart, eg, enhancing force development or producing ventricular diastolic dysfunction." @default.
• W2079498453 created "2016-06-24" @default.
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• W2079498453 date "1997-09-02" @default.
• W2079498453 modified "2023-10-16" @default.
• W2079498453 title "Troponin I Phosphorylation in the Normal and Failing Adult Human Heart" @default.
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• W2079498453 doi "https://doi.org/10.1161/01.cir.96.5.1495" @default.
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