FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079506095> ?p ?o ?g. }

• W2079506095 abstract "(1) To determine the brain connectivity pattern associated with clinical rigidity scores in Parkinson's disease (PD) and (2) to determine the relation between clinically assessed rigidity and quantitative metrics of motor performance.Rigidity, the resistance to passive movement, is exacerbated in PD by asking the subject to move the contralateral limb, implying that rigidity involves a distributed brain network. Rigidity mainly affects subjects when they attempt to move; yet the relation between clinical rigidity scores and quantitative aspects of motor performance are unknown.Ten clinically diagnosed PD patients (off-medication) and 10 controls were recruited to perform an fMRI squeeze-bulb tracking task that included both visually guided and internally guided features. The direct functional connectivity between anatomically defined regions of interest was assessed with Dynamic Bayesian Networks (DBNs). Tracking performance was assessed by fitting Linear Dynamical System (LDS) models to the motor performance, and was compared to the clinical rigidity scores. A cross-validated Least Absolute Shrinkage and Selection Operator (LASSO) regression method was used to determine the brain connectivity network that best predicted clinical rigidity scores.The damping ratio of the LDS models significantly correlated with clinical rigidity scores (p = 0.014). An fMRI connectivity network in subcortical and primary and premotor cortical regions accurately predicted clinical rigidity scores (p < 10(-5)).A widely distributed cortical/subcortical network is associated with rigidity observed in PD patients, which reinforces the importance of altered functional connectivity in the pathophysiology of PD. PD subjects with higher rigidity scores tend to have less overshoot in their tracking performance, and damping ratio may represent a robust, quantitative marker of the motoric effects of increasing rigidity." @default.
• W2079506095 created "2016-06-24" @default.
• W2079506095 creator A5010959399 @default.
• W2079506095 creator A5016910007 @default.
• W2079506095 creator A5051587486 @default.
• W2079506095 creator A5057809466 @default.
• W2079506095 creator A5070060161 @default.
• W2079506095 creator A5077155065 @default.
• W2079506095 creator A5080215539 @default.
• W2079506095 creator A5082214809 @default.
• W2079506095 date "2013-01-01" @default.
• W2079506095 modified "2023-10-17" @default.
• W2079506095 title "Parkinson’s Disease Rigidity: Relation to Brain Connectivity and Motor Performance" @default.
• W2079506095 cites W1965146525 @default.
• W2079506095 cites W1965324089 @default.
• W2079506095 cites W1973201554 @default.
• W2079506095 cites W1981640845 @default.
• W2079506095 cites W1986960825 @default.
• W2079506095 cites W1987576488 @default.
• W2079506095 cites W2002373649 @default.
• W2079506095 cites W2004631802 @default.
• W2079506095 cites W2008634332 @default.
• W2079506095 cites W2015749893 @default.
• W2079506095 cites W2025514142 @default.
• W2079506095 cites W2032629007 @default.
• W2079506095 cites W2043596296 @default.
• W2079506095 cites W2046198995 @default.
• W2079506095 cites W2049185404 @default.
• W2079506095 cites W2050430957 @default.
• W2079506095 cites W2057276513 @default.
• W2079506095 cites W2061376322 @default.
• W2079506095 cites W2061642378 @default.
• W2079506095 cites W2062656862 @default.
• W2079506095 cites W2064996887 @default.
• W2079506095 cites W2072371006 @default.
• W2079506095 cites W2074957274 @default.
• W2079506095 cites W2075050732 @default.
• W2079506095 cites W2078152479 @default.
• W2079506095 cites W2079016580 @default.
• W2079506095 cites W2084988311 @default.
• W2079506095 cites W2086701255 @default.
• W2079506095 cites W2096929469 @default.
• W2079506095 cites W2097421443 @default.
• W2079506095 cites W2099192744 @default.
• W2079506095 cites W2107628918 @default.
• W2079506095 cites W2124498607 @default.
• W2079506095 cites W2131153484 @default.
• W2079506095 cites W2134034633 @default.
• W2079506095 cites W2135046866 @default.
• W2079506095 cites W2138187186 @default.
• W2079506095 cites W2138969827 @default.
• W2079506095 cites W2152316935 @default.
• W2079506095 cites W2152387082 @default.
• W2079506095 cites W2154384688 @default.
• W2079506095 cites W2154435473 @default.
• W2079506095 cites W2158649190 @default.
• W2079506095 cites W2170976240 @default.
• W2079506095 cites W2171000498 @default.
• W2079506095 cites W2313354545 @default.
• W2079506095 cites W2417762263 @default.
• W2079506095 cites W2465328385 @default.
• W2079506095 cites W3034313911 @default.
• W2079506095 cites W39143648 @default.
• W2079506095 cites W80739781 @default.
• W2079506095 cites W2024278024 @default.
• W2079506095 cites W2025175823 @default.
• W2079506095 cites W2738740617 @default.
• W2079506095 doi "https://doi.org/10.3389/fneur.2013.00067" @default.
• W2079506095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3672800" @default.
• W2079506095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23761780" @default.
• W2079506095 hasPublicationYear "2013" @default.
• W2079506095 type Work @default.
• W2079506095 sameAs 2079506095 @default.
• W2079506095 citedByCount "49" @default.
• W2079506095 countsByYear W20795060952014 @default.
• W2079506095 countsByYear W20795060952015 @default.
• W2079506095 countsByYear W20795060952016 @default.
• W2079506095 countsByYear W20795060952017 @default.
• W2079506095 countsByYear W20795060952018 @default.
• W2079506095 countsByYear W20795060952019 @default.
• W2079506095 countsByYear W20795060952020 @default.
• W2079506095 countsByYear W20795060952021 @default.
• W2079506095 countsByYear W20795060952022 @default.
• W2079506095 countsByYear W20795060952023 @default.
• W2079506095 crossrefType "journal-article" @default.
• W2079506095 hasAuthorship W2079506095A5010959399 @default.
• W2079506095 hasAuthorship W2079506095A5016910007 @default.
• W2079506095 hasAuthorship W2079506095A5051587486 @default.
• W2079506095 hasAuthorship W2079506095A5057809466 @default.
• W2079506095 hasAuthorship W2079506095A5070060161 @default.
• W2079506095 hasAuthorship W2079506095A5077155065 @default.
• W2079506095 hasAuthorship W2079506095A5080215539 @default.
• W2079506095 hasAuthorship W2079506095A5082214809 @default.
• W2079506095 hasBestOaLocation W20795060951 @default.
• W2079506095 hasConcept C127413603 @default.
• W2079506095 hasConcept C142724271 @default.
• W2079506095 hasConcept C15744967 @default.
• W2079506095 hasConcept C160343418 @default.
• W2079506095 hasConcept C169760540 @default.
• W2079506095 hasConcept C2779134260 @default.

• next