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• W2079506489 abstract "The 90 kDa ribosomal S6 kinases (RSKs), especially RSK2, have attracted attention for the development of new anticancer agents. Through structural optimization of the hit compound 1 from our previous study, a series of barbituric acid aryl hydrazone analogues were designed and synthesized as potential RSK2 inhibitors. The most potent one, compound 9, showed a higher activity against RSK2 with an IC50 value of 1.95 μM. To analyze and elucidate their structure-activity relationship, the homology model of RSK2 N-terminal kinase domain was built and molecular docking simulations were performed, which provide helpful clues to design new inhibitors with desired activities." @default.
• W2079506489 created "2016-06-24" @default.
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• W2079506489 date "2012-04-30" @default.
• W2079506489 modified "2023-09-24" @default.
• W2079506489 title "Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors" @default.
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• W2079506489 doi "https://doi.org/10.3109/14756366.2012.681651" @default.
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