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• W2079507346 abstract "Les maladies cardiovasculaires restent la cause principale de mortalité. Quatre facteurs de risque modifiables jouent un rôle central et doivent être corrigés de façon optimale pour une prévention efficace de ces maladies cardiovasculaires. Le bénéfice des statines est directement fonction du risque cardiovasculaire quand on évalue ce bénéfice en nombre de patients à traiter pour éviter un événement. Par ailleurs le bénéfice des statines est aussi une fonction directe de l’amplitude de la baisse du LDL-cholestérol. Ces résultats démontrent l’importance pour les cliniciens d’identifier le risque cardiovasculaire des patients et d’obtenir une diminution importante du LDL-cholestérol dans les populations les plus à risque conformément aux recommandations nationales et internationales. Cardiovascular diseases remain the number one cause of death. Four independent modifiable risk factors play a central role in cardiovascular disease. Smoking, hypertension, diabetes and high serum levels of low-density lipoprotein cholesterol. Statin treatment is associated with a reduction in cardiovascular risk. When evaluated as the number-needed-to-treat to avoid one event the benefit is dramatic in all subgroups of patients at high risk. Since in parallel the benefit is a direct function of the magnitude of the decrease in low-density cholesterol, statin treatment should target patients at high risk and aim to reach the goal indicated in national and international guidelines. We review here the most frequent conditions associated with high cardiovascular risk and the data obtained with statin treatment." @default.
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• W2079507346 date "2012-12-01" @default.
• W2079507346 modified "2023-09-25" @default.
• W2079507346 title "Bénéfice cardiovasculaire des statines dans le haut risque vasculaire" @default.
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• W2079507346 doi "https://doi.org/10.1016/s1878-6480(12)70841-8" @default.
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